ArticleOrganic letters2023
Cu-Catalyzed Three-Component Carboamination of Electron Deficient Olefins.
Article in Organic letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Serendipity-Driven Telescoped Synthesis of 2-Aryl Glycidic Esters from Aldehydes.Organic letters · 2026Article
- Cu-Catalyzed Three-Component Carbofunctionalization of 1,3-Dienes.ACS catalysis · 2025Article
- Cu-Catalyzed Three-Component Alkene Carboamination: Mechanistic Insights and Rational Design to Overcome Limitations.Journal of the American Chemical Society · 2024Article
- Synthetic Utilization of 2The Journal of organic chemistry · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The copper-catalyzed three-component carboamination of atropates for the synthesis of α-aryl amino acid derivatives is presented. The scope of the reaction is explored with respect to all three coupling partners: the alkyl halide, the atropate, and the aryl amine. A total of 41 examples are included, with yields of ≤92%. Both primary and secondary aryl amines participate in the carboamination along with α-haloesters, nitriles, and perfluoroiodoalkanes. Mechanistic investigations support a radical mechanism involving Cu-mediated C-N bond formation with the radical adduct.
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Registered trials
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