Evidence map›Paper›PMID 37440083›Full record

ReviewAdvances in experimental medicine and biology2023

The Amphipathic Helix in Visual Cycle Proteins: A Review.

Sheetal Uppal, Eugenia Poliakov, Susan Gentleman, T Michael Redmond

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sheetal UppalLaboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Eugenia PoliakovLaboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Susan GentlemanLaboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
T Michael RedmondLaboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. redmondd@helix.nih.gov.
National Institutes of Health · USNational Eye Institute · US

Funding

Molecular Biology Of Outer Retina-specific ProteinsZIAEY000260 · NEI · NATIONAL EYE INSTITUTE · PI REDMOND, T. MICHAEL · 2009 to 2025
$26.0M
MOLECULAR BIOLOGY OF OUTER RETINA-SPECIFIC PROTEINSZ01EY000260 · NEI · NATIONAL EYE INSTITUTE · PI REDMOND, THOMAS M · 1990 to 2008
$3.7M
Intramural NIH HHS Z01 EY000260Intramural NIH HHS ZIA EY000260
6 · The paper itself

Abstract

The visual cycle is a complex biological process that involves the sequential action of proteins in the retinal pigment epithelial (RPE) cells and photoreceptors to modify and shuttle visual retinoids. A majority of the visual cycle proteins are membrane proteins, either integral or peripheral membrane proteins. Despite significant progress in understanding their physiological function, very limited structural information is available for the visual cycle proteins. Moreover, the mechanism of membrane interaction is not yet clear in all cases. Here, we demonstrate the presence of an amphipathic helix in selected RPE visual cycle proteins, using in silico tools, and highlight their role in membrane association and function.

Indexed as

Retinal Pigment EpitheliumRetinoidsCarrier Proteinscis-trans-IsomerasesEye ProteinsMembrane ProteinsCarrier Proteinscis-trans-IsomerasesEye ProteinsMembrane ProteinsRetinoidsAlpha (α)-helixAmphipathic helixCRALBPLRATMembrane associationRDH5RetinoidsRPE65Visual cycle proteins

Identifiers

PMID37440083
PMCPMC11299856
OpenAlexW4384120858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.