Understanding Ischemic Retinopathies: The Role of Succinate and Its Receptor in Retinal Pigment Epithelium.

Retinopathy is the general name for all condition of the eyes in which blood vessels that supply oxygen to the retina are damaged. These include diabetic retinopathy, retinopathy of prematurity, hypertensive retinopathy, and arteriosclerotic retinopathy. Although the initial trigger that leads to insufficient perfusion of the retina may be different, once a critical level of ischemia is achieved, all types of retinopathies seem to follow a common sequence-oxidative stress, followed by hypoxia-induced formation of morphologically abnormal vessels. This preretinal vascular growth is the most severe aspect of the retinopathy, as the outcome is often retinal detachment and eventually blindness. Regardless of which therapy strategy is followed, a deeper understanding of both normal retinal growth and the underlying molecular mechanisms of retinopathies is needed in order to come up with more effective therapies. This chapter focuses on the citric acid cycle intermediate succinate and its G protein-coupled receptor SUCNR1 in ischemic retinopathies, which were identified as potent mediators of vessel growth in the settings of both normal retinal development and proliferative ischemic retinopathies.