Evidence map›Paper›PMID 37440048›Full record

ArticleAdvances in experimental medicine and biology2023

Retinal Pathoconnectomics: A Window into Neurodegeneration.

Rebecca L Pfeiffer, Bryan W Jones

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rebecca L PfeifferJohn A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, UT, USA. r.pfeiffer@utah.edu.
Bryan W JonesJohn A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, UT, USA.
University of Utah · US

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Bryan William Jones · 2005 to 2026
$14.6M
STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITSR01EY002576 · NEI · UNIVERSITY OF UTAH · PI MARC, ROBERT E · 1985 to 2016
$8.0M
Retinal RemodelingR01EY015128 · NEI · UNIVERSITY OF UTAH · PI JONES, BRYAN WILLIAM · 2004 to 2021
$7.0M
Retinal CircuitryR01EY028927 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Bryan William Jones · 2019 to 2026
$5.2M
Vision Research Training Grant at the University of UtahT32EY024234 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DAVID KRIZAJ, Monica L Vetter · 2014 to 2026
$2.3M
NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY002576NEI NIH HHS R01 EY015128NEI NIH HHS R01 EY028927NEI NIH HHS T32 EY024234
6 · The paper itself

Abstract

Over the past decade, the field of retinal connectomics has made huge strides in describing the precise topologies underlying retinal visual processing. The same techniques that allowed these advancements are also applicable to understanding the progression of rewiring in retinal remodeling: retinal pathoconnectomics. Pathoconnectomics is unique in its unbiased approach to understanding the impacts of deafferentation on the remaining network components and identifying aberrant connectivities leading to visual processing defects. Pathoconnectomics also paves the way for identifying underlying rules of rewiring that may be recapitulated throughout the nervous system in other neurodegenerative diseases.

Indexed as

RetinaRetinal DegenerationHumansConnectomicsEarly retinal degenerationNeural networksNeurodegenerationPathoconnectomeRetinal remodelingUltrastructure

Identifiers

PMID37440048
PMCPMC11342915
OpenAlexW4384120201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.