Evidence map›Paper›PMID 37440046›Full record

ArticleAdvances in experimental medicine and biology2023

Human Mutations in Arl3, a Small GTPase Involved in Lipidated Cargo Delivery to the Cilia, Cause Retinal Dystrophy.

Amanda M Travis, Jillian N Pearring

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amanda M TravisDepartment of Ophthalmology and Visual Science, University of Michigan, Ann Arbor, MI, USA.
Jillian N PearringDepartment of Ophthalmology and Visual Science, University of Michigan, Ann Arbor, MI, USA. pearring@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Understanding Photoreceptor Trafficking Pathways to the Outer SegmentR00EY025732 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PEARRING, JILLIAN NYDAM · 2018 to 2020
$887k
NEI NIH HHS R00 EY025732
6 · The paper itself

Abstract

Photoreceptors are highly polarized sensory neurons. Precise localization of signaling molecules within the ciliary outer segment is critical for photoreceptor function and viability. The small GTPase Arl3 plays a particularly important role in photoreceptors as it regulates outer segment enrichment of lipidated proteins essential for the visual response: transducin-α, transducin-γ, PDEα, PDE β, and Grk1. Recently, mutations in Arl3 have been identified in human patients with nonsyndromic autosomal recessive and dominant inherited retinal degenerations as well as syndromic Joubert syndrome including retinal dystrophy.

Indexed as

Monomeric GTP-Binding ProteinsRetinal DystrophiesADP-Ribosylation FactorsCiliaHumansMutationTransducinADP-Ribosylation FactorsMonomeric GTP-Binding ProteinsTransducinArl13BArl3PhotoreceptorsRetinal dystrophyRP2

Identifiers

PMID37440046
OpenAlexW4384126465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.