Evidence map›Paper›PMID 37439940›Full record

ArticleEuropean radiology2023

Using a CT-based scale to evaluate disease extension and the resectability of locally advanced thyroid cancer.

Nai-Si Huang, Qiao Li, Xin-Yi Gao, Shi-Yu Xiang, Qing-Hai Ji, Jun Xiang, Yu-Long Wang, Wen-Jun Wei, Jia-Ying Chen, Qing Yu and 4 more

Abstract read
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In one paragraph

Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nai-Si Huang *Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd, Shanghai, China.
Qiao Li *Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Xin-Yi Gao *Shanghai Institute of Medical Imaging, 180 Fenglin Road, Shanghai, 200032, China.
Shi-Yu XiangDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Qing-Hai JiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd, Shanghai, China. jq_hai@126.com.
Jun XiangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd, Shanghai, China.
Yu-Long WangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd, Shanghai, China.
Wen-Jun WeiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd, Shanghai, China.
Jia-Ying ChenDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd, Shanghai, China.
Qing YuInstitute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, 1 Banshan East Road, Hangzhou, 310022, Zhejiang, China.
Yi-Ming CaoDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd, Shanghai, China.
Qing GuanDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd, Shanghai, China.
Ya-Jia GuDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. guyajia@126.com.
Yu WangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd, Shanghai, China. neck130@hotmail.com.

Funding

National Natural Science Foundation of China 81902721National Natural Science Foundation of China 82072951Shanghai Hospital Development Centre Clinical Research SHDC2020CR6003the Science and Technology commission of Shanghai Municipality 19411966600Zhuhai Fudan Innovation Institute 20665
6 · The paper itself

Abstract

objectivesTo establish a computed tomography (CT)-based scale to evaluate the resectability of locally advanced thyroid cancer.

methodsThis twin-centre retrospective study included 95 locally advanced thyroid cancer patients from the 1

resultsIn the training cohort, compromised RLN (p < 0.001), trachea (p = 0.001), oesophagus (p = 0.002), artery (p < 0.001), vein (p = 0.005), and soft tissue (p < 0.001) were predictors for unresectability, while compromised larynx (p = 0.283) was not. The 12-score scale (AUC = 0.882, 95%CI: 0.812-0.952) was not inferior to the 14-score scale (AUC = 0.891, 95%CI: 0.823-0.960). In subgroup analysis, the AUCs of the 12-score scale were 0.826 for treatment-naïve patients and 0.976 for patients with prior surgery. The 12-score scale was further validated with a fivefold cross-validation analysis, with an overall accuracy of 78.9-89.4%. Finally, external validation using the testing cohort showed an AUC of 0.875.

conclusionsThe researchers built a CT-based 12-score scale to evaluate the resectability of locally advanced thyroid cancer. Validation with a larger sample size is required to confirm the efficacy of the scale. CLINICAL RELEVANCE STATEMENT: This 12-score CT scale would help clinicians evaluate the resectability of locally advanced thyroid cancer. KEY POINTS: • The researchers built a 12-score CT scale (including recurrent laryngeal nerve, trachea, oesophagus, artery, vein, and soft tissue) to evaluate the resectability of locally advanced thyroid cancer. • This scale has the potential to help clinicians make treatment plans for locally advanced thyroid cancer.

Indexed as

LarynxThyroid NeoplasmsHumansRetrospective StudiesTomography, X-Ray ComputedClinical decision rulesMargins of excisionThyroidectomyThyroid neoplasmsTomography, X-ray computed

Identifiers

PMID37439940

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.