Evidence map›Paper›PMID 37439857›Full record

ArticleActa diabetologica2023

Association between urinary C-megalin levels and progressive kidney dysfunction: a cohort study based on the diabetes distress and care registry at Tenri (DDCRT 24).

Kakuya Niihata, Hiroki Nishiwaki, Maki Kinoshita, Kentaro Kurosawa, Yui Sakuramachi, Satoshi Matsunaga, Shintaro Okamura, Satoru Tsujii, Yasuaki Hayashino, Noriaki Kurita and 1 more

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Article in Acta diabetologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kakuya NiihataDepartment of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, Fukushima, Fukushima, Japan. niihata9@fmu.ac.jp.ORCID http://orcid.org/0000-0001-9836-5750
Hiroki NishiwakiDepartment of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, Fukushima, Fukushima, Japan.
Maki KinoshitaDepartment of Clinical Laboratory, Tenri Hospital, Nara, Tenri, Japan.
Kentaro KurosawaDepartment of Endocrinology, Tenri Hospital, Nara, Tenri, Japan.
Yui SakuramachiDepartment of Endocrinology, Tenri Hospital, Nara, Tenri, Japan.
Satoshi MatsunagaDepartment of Endocrinology, Tenri Hospital, Nara, Tenri, Japan.
Shintaro OkamuraDepartment of Endocrinology, Tenri Hospital, Nara, Tenri, Japan.
Satoru TsujiiDepartment of Endocrinology, Tenri Hospital, Nara, Tenri, Japan.
Yasuaki HayashinoDepartment of Endocrinology, Tenri Hospital, Nara, Tenri, Japan.
Noriaki KuritaDepartment of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, Fukushima, Fukushima, Japan.
Diabetes Distress and Care Registry at Tenri Study Group

Funding

Japan Society for the Promotion of Science 25460641/16K08897
6 · The paper itself

Abstract

aimsThe aim of this cohort study was to evaluate the association between urinary levels of C-megalin, a full-length form of megalin, and kidney dysfunction progression and its dependence on the urinary albumin-creatinine ratio (UACR) in individuals with diabetes.

methodsWe enrolled 1,547 individuals with diabetes who visited the ambulatory clinic at Tenri Hospital, a regional tertiary-care hospital in Tenri City, Nara Prefecture, Japan, with an estimated glomerular filtration (eGFR) of ≥ 30 mL/min/1.73 m

resultsUrinary C-megalin level was not associated with ≥ 40% eGFR decline in an age-, sex-, eGFR-, systolic blood pressure-, hemoglobin-, and UACR-adjusted model in the 1,547 patients enrolled in the study. However, urinary C-megalin levels were associated with a ≥ 40% decline in eGFR when accounting for the relationship between urinary C-megalin levels and UACR in the model. This association was UACR-dependent.

conclusionsHigh urinary C-megalin levels were associated with progressive kidney dysfunction in individuals with diabetes, and this association was attenuated by high UACRs.

Indexed as

Diabetes Mellitus, Type 2Low Density Lipoprotein Receptor-Related Protein-2AlbuminuriaCohort StudiesGlomerular Filtration RateHumansKidneyRegistriesLow Density Lipoprotein Receptor-Related Protein-2DiabetesKidney dysfunctionMegalinUrinary albumin-creatinine ratio

Identifiers

PMID37439857

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