Evidence map›Paper›PMID 37439681›Full record

ArticleMicrobiology spectrum2023

Short-Term Dietary Intervention with Whole Oats Protects from Antibiotic-Induced Dysbiosis.

Stephen K Costa, Katherine Antosca, Chapman N Beekman, Rachel L Peterson, Swathi Penumutchu, Peter Belenky

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Stephen K CostaDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Katherine AntoscaDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Chapman N BeekmanDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Rachel L PetersonDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Swathi PenumutchuDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Peter BelenkyDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.ORCID 0000-0002-1682-945X
Brown University · US

Funding

Relating impacts of antibiotics on the gut metabolome and microbiome to host physiology and weight.R01DK125382 · NIDDK · BROWN UNIVERSITY · PI BELENKY, PETER · 2020 to 2024
$2.7M
Dietary fiber to mitigate antibiotic-induced microbiome dysbiosis: a multi-omics approachR21AT010366 · NCCIH · BROWN UNIVERSITY · PI BELENKY, PETER · 2019 to 2020
$447k
NCCIH NIH HHS R21 AT010366NIDDK NIH HHS R01 DK125382
6 · The paper itself

Abstract

Antibiotic-induced gut microbiome dysbiosis (AID) is known to be influenced by host dietary composition. However, how and when diet modulates gut dysbiosis remains poorly characterized. Thus, here, we utilize a multi-omics approach to characterize how a diet supplemented with oats, a rich source of microbiota-accessible carbohydrates, or dextrose impacts amoxicillin-induced changes to gut microbiome structure and transcriptional activity. We demonstrate that oat administration during amoxicillin challenge provides greater protection from AID than the always oats or recovery oats diet groups. In particular, the group in which oats were provided at the time of antibiotic exposure induced the greatest protection against AID while the other oat diets saw greater effects after amoxicillin challenge. The oat diets likewise reduced amoxicillin-driven elimination of

Indexed as

Anti-Bacterial AgentsAvenaAmoxicillinCarbohydratesDysbiosisGlucoseAmoxicillinAnti-Bacterial AgentsCarbohydratesGlucoseantibiotic-induced dysbiosisdysbiosisgut microbiomemicrobiome

Identifiers

PMID37439681
PMCPMC10434222
OpenAlexW4384126668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.