Evidence map›Paper›PMID 37439570›Full record

ArticlemSystems2023

Intensive care unit sinks are persistently colonized with multidrug resistant bacteria and mobilizable, resistance-conferring plasmids.

Luke Diorio-Toth, Meghan A Wallace, Christopher W Farnsworth, Bin Wang, Danish Gul, Jennie H Kwon, Saadia Andleeb, Carey-Ann D Burnham, Gautam Dantas

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. International journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Observational
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. The indoors microbiome and human health.Nature reviews. Microbiology · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Luke Diorio-TothThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine , St. Louis, Missouri, USA.ORCID 0000-0002-6586-2811
Meghan A WallaceDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine , St. Louis, Missouri, USA.
Christopher W FarnsworthDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine , St. Louis, Missouri, USA.ORCID 0000-0001-7169-3850
Bin WangThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine , St. Louis, Missouri, USA.
Danish GulAtta ur Rahman School of Applied Biosciences, National University of Sciences and Technology , Islamabad, Pakistan.
Jennie H KwonDepartment of Medicine, Washington University School of Medicine in St Louis , St. Louis, Missouri, USA.
Saadia AndleebAtta ur Rahman School of Applied Biosciences, National University of Sciences and Technology , Islamabad, Pakistan.
Carey-Ann D BurnhamDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine , St. Louis, Missouri, USA.ORCID 0000-0002-1137-840X
Gautam DantasThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine , St. Louis, Missouri, USA.ORCID 0000-0003-0455-8370
Washington University in St. Louis · USNational University of Sciences and Technology · PK

Funding

STRUCTURAL, MECHANISTIC, & EVOLUTIONARY CHARACTERIZATION OF TETRACYCLINE DESTRUCTASESU01AI123394 · NIAID · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM, WENCEWICZ, TIMOTHY ADAM · 2020 to 2025
$4.1M
PHYLOGENOMIC, TRANSCRIPTOMIC, VIROMIC, AND IMMUNOPROTEOMIC DETERMINANTS OF NECROTIZING ENTEROCOLITISR01HD092414 · NICHD · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM, TARR, PHILLIP I · 2017 to 2021
$3.0M
Mapping the evolutionary landscape of a novel family of tetracycline resistance enzymesF30AI157161 · NIAID · WASHINGTON UNIVERSITY · PI DIORIO-TOTH, LUKE EVAN · 2021 to 2023
$117k
NIAID NIH HHS F30 AI157161NIAID NIH HHS U01 AI123394NICHD NIH HHS R01 HD092414
6 · The paper itself

Abstract

Contamination of hospital sinks with microbial pathogens presents a serious potential threat to patients, but our understanding of sink colonization dynamics is largely based on infection outbreaks. Here, we investigate the colonization patterns of multidrug-resistant organisms (MDROs) in intensive care unit sinks and water from two hospitals in the USA and Pakistan collected over 27 months of prospective sampling. Using culture-based methods, we recovered 822 bacterial isolates representing 104 unique species and genomospecies. Genomic analyses revealed long-term colonization by

Indexed as

Drug Resistance, Multiple, BacterialIntensive Care UnitsAnti-Bacterial AgentsBacteriaHumansPlasmidsProspective StudiesAnti-Bacterial Agentsantimicrobial resistancegenomic epidemiologyhorizontal gene transferhospital surveillanceplasmid ecologywhole-genome sequencing

Identifiers

PMID37439570
PMCPMC10469867
OpenAlexW4384120789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.