Evidence map›Paper›PMID 37439558›Full record

ArticlemSystems2023

TLR2 is non-redundant in the population and subpopulation responses to

Charul Jani, Sydney L Solomon, Joshua M Peters, Stephanie C Pringle, Amelia E Hinman, Julie Boucau, Bryan D Bryson, Amy K Barczak

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. mBio · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Charul Jani *The Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.
Sydney L Solomon *The Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.
Joshua M PetersThe Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.
Stephanie C PringleThe Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.
Amelia E HinmanThe Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.
Julie BoucauThe Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.
Bryan D Bryson *The Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.ORCID 0000-0003-1716-6712
Amy K Barczak *The Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.ORCID 0000-0003-3806-2381
Ragon Institute of MGH, MIT and Harvard · USHarvard University · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG, GEORG Michael LAUER · 2009 to 2026
$48.1M
Dynamics of the cellular and molecular architecture of human pulmonary TB granulomasR01AI166313 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$3.2M
Elucidating the path to type I IFNs in TB infectionR01AI150762 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BARCZAK, AMY K · 2021 to 2025
$3.2M
NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI150762NIAID NIH HHS R01 AI166313NIAID NIH HHS U19 AI082630
6 · The paper itself

Abstract

Tuberculosis (TB), caused by the pathogenic bacterium

Indexed as

Host-Pathogen InteractionsMacrophagesMycobacterium tuberculosisToll-Like Receptor 2TuberculosisAnimalsCells, CulturedCellular MicroenvironmentInterferon Type IMiceMicrobial ViabilityNF-kappa BPathogen-Associated Molecular Pattern MoleculesInterferon Type INF-kappa BPathogen-Associated Molecular Pattern MoleculesTlr2 protein, mouseToll-Like Receptor 2innate immunitymacrophagemycobacteriaMycobacterium tuberculosissingle-cell RNAseqTLR2tuberculosis

Identifiers

PMID37439558
PMCPMC10506474
OpenAlexW4384120229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.