Evidence map›Paper›PMID 37439502›Full record

ReviewNatural product reports2023

Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018-2022.

Sunmin Woo, Lewis Marquez, William J Crandall, Caitlin J Risener, Cassandra L Quave

Open access · greenAbstract readReview
In one paragraph

Review in Natural product reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  10. Efficacy of Cannabidiol in Reducing Virulence ofInternational journal of molecular sciences · 2026
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  19. Frontiers in microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sunmin WooCenter for the Study of Human Health, Emory University, USA.ORCID 0000-0001-7561-2333
Lewis MarquezMolecular and Systems Pharmacology Program, Laney Graduate School, Emory University, USA.
William J CrandallMolecular and Systems Pharmacology Program, Laney Graduate School, Emory University, USA.ORCID 0000-0002-2537-2033
Caitlin J RisenerMolecular and Systems Pharmacology Program, Laney Graduate School, Emory University, USA.ORCID 0000-0002-4824-6064
Cassandra L QuaveCenter for the Study of Human Health, Emory University, USA.ORCID 0000-0001-9615-7886
Emory University · US

Funding

Development and validation of a high-throughput MicroED-driven platform technology for natural product discoveryR01AT011990 · NCCIH · EMORY UNIVERSITY · PI Hosea Martin Nelson, CASSANDRA LEAH QUAVE · 2022 to 2026
$3.2M
Contributions of host and gut microbial mediated metabolism to the antiviral activity of elderberryF31AT012140 · NCCIH · EMORY UNIVERSITY · PI CRANDALL, WILLIAM JOSEPH · 2022 to 2024
$143k
Exploring the Potential of Natural Products to Combat COVID-19F31AT011988 · NCCIH · EMORY UNIVERSITY · PI RISENER, CAITLIN JAIME · 2022 to 2023
$82k
NCCIH NIH HHS F31 AT011988NCCIH NIH HHS F31 AT012140NCCIH NIH HHS R01 AT011990
6 · The paper itself

Abstract

Covering: 2018 to 2022Antimicrobial resistance (AMR) poses a significant global health threat. There is a rising demand for innovative drug scaffolds and new targets to combat multidrug-resistant bacteria. Before the advent of antibiotics, infections were treated with plants chosen from traditional medicine practices. Of Earth's 374 000 plant species, approximately 9% have been used medicinally, but most species remain to be investigated. This review illuminates discoveries of antimicrobial natural products from plants covering 2018 to 2022. It highlights plant-derived natural products with antibacterial, antivirulence, and antibiofilm activity documented in lab studies. Additionally, this review examines the development of novel derivatives from well-studied parent natural products, as natural product derivatives have often served as scaffolds for anti-infective agents.

Indexed as

Anti-Infective AgentsBiological ProductsAnti-Bacterial AgentsPlantsAnti-Bacterial AgentsAnti-Infective AgentsBiological Products

Identifiers

PMID37439502
PMCPMC10472255
OpenAlexW4384120551

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.