Evidence map›Paper›PMID 37439351›Full record

ArticleAmerican journal of hypertension2023

Specialized Pro-resolving Mediator Improves Vascular Relaxation via Formyl Peptide Receptor-2.

Jonnelle M Edwards-Glenn, Milene T Fontes, Emily W Waigi, Tiago J Costa, Andrei Maiseyeu, R Clinton Webb, Cameron G McCarthy, Camilla F Wenceslau

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Maresin 1 modulates renal and cardiac lipid profiles in hypertensive rats.American journal of physiology. Renal physiology · 2025
    Article
  5. Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction.Basic & clinical pharmacology & toxicology · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jonnelle M Edwards-GlennCardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Milene T FontesCardiovascular Translational Research Center, Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Emily W WaigiCardiovascular Translational Research Center, Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Tiago J CostaCardiovascular Translational Research Center, Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Andrei MaiseyeuCardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
R Clinton WebbCardiovascular Translational Research Center, Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Cameron G McCarthyCardiovascular Translational Research Center, Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Camilla F WenceslauCardiovascular Translational Research Center, Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA.ORCID 0000-0002-0815-3568
University of South Carolina · USUniversity School · US

Funding

Targeting early ceramide elevation in pre-symptomatic eczemaP20GM103641 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ENOS, REILLY, NAGARKATTI, PRAKASH S · 2012 to 2023
$20.7M
Toll-like receptor 9 activation by mitochondrial DNA causes vascular injury in hypertensionP01HL134604 · NHLBI · AUGUSTA UNIVERSITY · PI BRANDS, MICHAEL W. · 2017 to 2021
$9.4M
Formyl peptide receptor activation induces vascular plasticity and remodeling inhypertensionR01HL149762 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WENCESLAU, CAMILLA FERREIRA · 2021 to 2025
$1.9M
Intrarenal Arteries Sense N-formyl Peptides Leading to Vascular Injury in SepsisR00GM118885 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WENCESLAU, CAMILLA FERREIRA · 2019 to 2021
$746k
Autophagy regulates β-hydroxybutyrate synthesis to prevent hypertension-associated premature vascular agingR00HL151889 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MCCARTHY, CAMERON · 2022 to 2024
$742k
NHLBI NIH HHS P01 HL134604NHLBI NIH HHS R00 HL151889NHLBI NIH HHS R01 HL149762NIGMS NIH HHS P20 GM103641NIGMS NIH HHS R00 GM118885
6 · The paper itself

Abstract

backgroundThe resolution of inflammation is an active phenomenon important for switching off inflammatory processes once the harmful stimuli are removed and facilitate the return to homeostasis. Specialized pro-resolving mediators (SPMs), such as lipoxin A4, resolvin D1, and resolvin E1, derived from ω-3 or ω-6 polyunsaturated fatty acids, are crucial for the resolution of inflammation. We hypothesized that SPMs are decreased in hypertension which contributes to the acetylcholine-induced contraction in resistance arteries, which are well known to be mediated by leukotrienes and prostaglandins. Moreover, treatment with SPMs will decrease this contraction via formyl peptide receptor-2 (FPR-2) in resistance arteries from spontaneously hypertensive rats (SHR). METHODS AND

resultsWe performed a comprehensive eicosanoid lipid panel analysis, and our data showed for the first time that precursors of SPMs are decreased in SHR, limiting the production of SPMs and resolution of inflammation in vivo. This phenomenon was associated with an increase in lipid peroxidation in resistance arteries. Although SPMs did not abolish acetylcholine-induced contraction, these lipid mediators improved endothelial function in arteries from SHR via FPR-2 activation at nanomolar concentrations. SPMs also buffered TNF-α-induced reactive oxygen species generation in endothelial cells from C57Bl/6 mice.

conclusionsWe suggest that FPR-2 and SPMs could be revealed as a new target or therapeutic agent to improve vascular function in arteries from hypertensive rats.

Indexed as

AcetylcholineReceptors, Formyl PeptideAnimalsDocosahexaenoic AcidsEndothelial CellsInflammationInflammation MediatorsMiceRatsAcetylcholineDocosahexaenoic Acidsformyl peptide receptor 2, mouseInflammation MediatorsReceptors, Formyl Peptideblood pressureendothelial dysfunctionhypertensionresolution of inflammation

Identifiers

PMID37439351
PMCPMC10502783
OpenAlexW4384119490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.