Evidence map›Paper›PMID 37439349›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2023

A new insight of immunosuppressive microenvironment in osteosarcoma lung metastasis.

Mingwei He, Xiaohong Jiang, Jifeng Miao, Wenyu Feng, Tianyu Xie, Shijie Liao, Zhaojie Qin, Haijun Tang, Chengsen Lin, Boxiang Li and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 29 citations in OpenAlex.

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  19. Methyltransferase-Like 3-Mediated NJournal of cellular and molecular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Mingwei HeDepartment of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Xiaohong JiangDepartment of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Jifeng MiaoOrthopedics Department, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530005, China.
Wenyu FengOrthopedics Department, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530005, China.
Tianyu XieDepartment of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Shijie LiaoDepartment of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Zhaojie QinDepartment of Orthopedic, The People's Hospital of Hechi, Hechi 547600, China.
Haijun TangDepartment of Spinal Bone Disease, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Chengsen LinDepartment of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Boxiang LiDepartment of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Jiake XuSchool of Biomedical Sciences, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0001-6712-5084
Yun LiuCollaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China.
Zengnan MoCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, China.
Qingjun WeiDepartment of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.ORCID 0000-0003-0570-4085
Guangxi Medical University · CNHechi University · CNThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lung is the primary organ for the metastasis of osteosarcoma. Although the application of neoadjuvant chemotherapy and surgery has remarkably improved the survival rate of patients with osteosarcoma, prognosis is still poor for those patients with metastasis. In this study, we performed further bioinformatics analysis on single-cell RNA sequencing (scRNA-seq) data published before, containing 75,317 cells from two osteosarcoma lung metastasis and five normal lung tissues. First, we classified 17 clusters, including macrophages, T cells, endothelial cells, and so on, indicating highly intratumoral heterogeneity in osteosarcoma lung metastasis. Next, we found macrophages in osteosarcoma lung metastasis did not have significant M1 or M2 polarizations. Then, we identified that T cells occupied the most abundant among all cell clusters, and found CD8

Indexed as

Bone NeoplasmsLung NeoplasmsOsteosarcomaCD8-Positive T-LymphocytesEndothelial CellsHumansImmunosuppressive AgentsLovastatinTumor MicroenvironmentImmunosuppressive AgentsLovastatinmevastatinimmune microenvironmentintratumoral heterogeneitylung metastasisosteosarcomasingle-cell RNA sequencing

Identifiers

PMID37439349
PMCPMC10581164
OpenAlexW4384119880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.