Evidence map›Paper›PMID 37439286›Full record

ArticleHead & neck2023

Concurrent carboplatin and paclitaxel definitive radiation therapy for locally advanced head and neck cancer.

James Han, Kaveh Zakeri, Gabriel Raab, Jennifer Hesse, Achraf Shamseddine, Linda Chen, Yao Yu, Jung Julie Kang, Sean M McBride, Nadeem Riaz and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Head & neck, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Carboplatin/Paclitaxel can be an effective alternative for cisplatin-ineligible patients with locally advanced HNSCC.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
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  6. Review
  7. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

James HanDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-0417-3879
Kaveh ZakeriDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0003-3921-480X
Gabriel RaabDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jennifer HesseDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Achraf ShamseddineDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Linda ChenDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Yao YuDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jung Julie KangDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Sean M McBrideDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nadeem RiazDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
C Jillian TsaiDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0003-0400-2655
Daphna GelblumDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Eric J ShermanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Richard J WongDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Loren MichelDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nancy Y LeeDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundWe report the outcomes of cisplatin-ineligible HNSCC patients treated with definitive chemoradiation and concurrent carboplatin and paclitaxel. MATERIALS AND

methodsWe included consecutive HNSCC patients treated from 2013 to 2021 that received definitive chemoradiation with carboplatin and paclitaxel. Locoregional recurrences (LRR) and distant metastases (DM) were estimated using cumulative incidence functions. Progression free survival (PFS) and overall survival (OS) were estimated using Kaplan-Meier methods.

resultsSixty-five patients were identified with median age of 71 years (range 44-85). Median radiation dose was 70 Gy and the median doses of carboplatin and paclitaxel were AUC 1 and 40 mg/m

conclusionsChemoradiation with carboplatin and paclitaxel is an excellent option for cisplatin-ineligible HNSCC patients.

Indexed as

Head and Neck NeoplasmsPaclitaxelAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCarboplatinChemoradiotherapyCisplatinHumansMiddle AgedNeoplasm Recurrence, LocalSquamous Cell Carcinoma of Head and NeckCarboplatinCisplatinPaclitaxelcisplatin ineligibleconcurrent carboplatin and paclitaxellocally advanced head and neck cancerolder age and comorbidities

Identifiers

PMID37439286
PMCPMC10981461
OpenAlexW4384120379

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.