ArticleJournal of applied physiology (Bethesda, Md. : 1985)2023
Regional lung perfusion using different indicators in electrical impedance tomography.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- The impact of metabolic syndrome on regional ventilation and perfusion in ARDS: an observational cohort study using electrical impedance tomography.Intensive care medicine experimental · 2026Article
- Electrical Impedance Tomography-Informed Regional Functional Phenotypes in Sepsis-Associated Acute Respiratory Distress Syndrome.Journal of inflammation research · 2026Review
- Electrical impedance tomography in congenital heart disease: advancing non-invasive pulmonary perfusion assessment at bedside.Intensive care medicine experimental · 2025Article
- Comparison of 5% sodium bicarbonate and 10% sodium chloride as contrast agents for lung perfusion with electrical impedance tomography: a prospective clinical study.BMC pulmonary medicine · 2025Article
- Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions.Critical care (London, England) · 2024Review
- Imaging the Lung in ARDS: A Primer.Respiratory care · 2024Review
- Time-domain and 3D methods for lung perfusion data clustering in electrical impedance tomography.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Imaging the pulmonary vasculature in acute respiratory distress syndrome.Nitric oxide : biology and chemistry · 2024Review
- First-Pass Kinetics Model to Estimate Pulmonary Perfusion by Electrical Impedance Tomography During Uninterrupted Breathing.American journal of respiratory and critical care medicine · 2024Article
- Electrical Impedance Tomography Identifies Evolution of Regional Perfusion in a Porcine Model of Acute Respiratory Distress Syndrome.Anesthesiology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Management of acute respiratory distress syndrome (ARDS) is classically guided by protecting the injured lung and mitigating damage from mechanical ventilation. Yet the natural history of ARDS is also dictated by disruption in lung perfusion. Unfortunately, diagnosis and treatment are hampered by the lack of bedside perfusion monitoring. Electrical impedance tomography is a portable imaging technique that can estimate regional lung perfusion in experimental settings from the kinetic analysis of a bolus of an indicator with high conductivity. Hypertonic sodium chloride has been the standard indicator. However, hypertonic sodium chloride is often inaccessible in the hospital, limiting practical adoption. We investigated whether regional lung perfusion measured using electrical impedance tomography is comparable between indicators. Using a swine lung injury model, we determined regional lung perfusion (% of total perfusion) in five pigs, comparing 12% sodium chloride to 8.4% sodium bicarbonate across stages of lung injury and experimental conditions (body position, positive end-expiratory pressure). Regional lung perfusion for four lung regions was determined from maximum slope analysis of the indicator-based impedance signal. Estimates of regional lung perfusion between indicators were compared in the lung overall and within four lung regions. Regional lung perfusion estimated with a sodium bicarbonate indicator agreed with a hypertonic sodium chloride indicator overall (mean bias 0%, limits of agreement -8.43%, 8.43%) and within lung quadrants. The difference in regional lung perfusion between indicators did not change across experimental conditions. Sodium bicarbonate may be a comparable indicator to estimate regional lung perfusion using electrical impedance tomography.
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