Evidence map›Paper›PMID 37439179›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Structural changes of the frontal cortex in depressed mice are associated with decreased expression of brain-derived neurotrophic factor].

W Cui, L Gong, C Chen, J Tang, X Jin, Z Li, L Jing, G Wen

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

W CuiMedical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
L GongMedical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
C ChenSecond Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
J TangFirst Clinical Medical College, Southern Medical University, Guangzhou 510515, China.
X JinFirst Clinical Medical College, Southern Medical University, Guangzhou 510515, China.
Z LiFirst Clinical Medical College, Southern Medical University, Guangzhou 510515, China.
L JingOperating Theater, TCM Integrated Hospital of Southern Medical University, Guangzhou 510315, China.
G WenMedical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Southern Medical University · CNNanfang Hospital · CNGuangzhou University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the changes in gray matter volume in depressive-like mice and explore the possible mechanism.

methodsTwenty-four 6-week-old C57 mice were randomized equally into control group and model group, and the mice in the model group were subjected to chronic unpredictable mild stimulation (CUMS) for 35 days. Magnetic resonance imaging was performed to examine structural changes of the grey matter volume in depressive-like mice. The expression of brain-derived neurotrophic factor (BDNF) in the grey matter of the mice was detected using Western blotting and immunofluorescence staining.

resultsCompared with the control mice, the mice with CUMS showed significantly decreased central walking distance in the open field test (

conclusionThe decrease of frontal cortex volume after CUMS is related with the reduction of mature BDNF expression in the frontal cortex.

Indexed as

Brain-Derived Neurotrophic FactorDepressionFrontal LobeAnimalsBlotting, WesternCerebral CortexMiceBdnf protein, mouseBrain-Derived Neurotrophic Factorbrain-derived neurotrophic factorchronic unpredictable mild stimulationvoxel-based morphometry

Identifiers

PMID37439179
PMCPMC10339313
OpenAlexW4384120200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.