Evidence map›Paper›PMID 37439160›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Notch signaling pathway inhibitor DAPT improves alcohol-induced neuronal differentiation impairment in zebrafish].

G Yin, R Li, Y Liu, X Wang, B Wu

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

G YinMedical Research Center of Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
R LiDepartment of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, China.
Y LiuDepartment of Neurology, Liaocheng People's Hospital, Liaocheng 252000, China.
X WangMedical Research Center of Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
B WuMedical Research Center of Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Guangzhou Medical University · CNLiaocheng People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the role of the Notch signaling pathway in regulating neuronal differentiation and sensorimotor ability in a zebrafish model of fetal alcohol spectrum disorder.

methodsZebrafish embryos treated with DMSO or 50 μmol/L DAPT (a Notch signaling pathway inhibitor) were examined for mortality rate, hatching rate, malformation rate, and body length at 15 days post fertilization (dpf). The mRNA expression levels of

resultsExposure to 50 μmol/L DAPT significantly increased the mortality rate of 1 dpf zebrafish embryos (

conclusionEthanol exposure causes upregulation of the Notch signaling pathway and impairs neuronal differentiation and sensorimotor ability of zebrafish embryos, and these detrimental effects can be lessened by inhibiting the Notch signaling pathway.

Indexed as

Antineoplastic AgentsZebrafishAmyloid Precursor Protein SecretasesAnimalsDimethyl SulfoxideEthanolPlatelet Aggregation InhibitorsSignal TransductionAmyloid Precursor Protein SecretasesAntineoplastic AgentsDimethyl SulfoxideEthanolPlatelet Aggregation InhibitorsDAPTethanolfetal alcohol spectrum disorderneuronal differentiationNotch signaling pathway

Identifiers

PMID37439160
PMCPMC10339305
OpenAlexW4384120751

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.