Evidence map›Paper›PMID 37438776›Full record

ArticleTrials2023

Randomised controlled trials of behavioural nudges delivered through text messages to increase influenza and COVID-19 vaccines among pregnant women (the EPIC study): study protocol.

Prabha H Andraweera, Bing Wang, Margie Danchin, Christopher Blyth, Ivo Vlaev, Jason Ong, Jodie Dodd, Jennifer Couper, Thomas R Sullivan, Jonathan Karnon and 10 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05613751 (Enhancing Protection Against Influenza and COVID-19 for Pregnant Women and Medically at Risk Children), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05613751 naunknown statusnot on this map

Enhancing Protection Against Influenza and COVID-19 for Pregnant Women and Medically at Risk Children (EPIC Study)

TypeinterventionalSponsorUniversity of AdelaideRan2022 to 2024Enrolled1,038ConditionsInfluenza, COVID-19ArmsNudge
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 2 countries.

Prabha H AndraweeraVaccinology and Immunology Research Trials Unit, Women's and Children's Hospital, SA Health, Adelaide, South Australia, Australia.
Bing WangVaccinology and Immunology Research Trials Unit, Women's and Children's Hospital, SA Health, Adelaide, South Australia, Australia.
Margie DanchinThe Royal Children's Hospital, Melbourne, Victoria, Australia.
Christopher BlythPerth Children's Hospital, Perth, Western Australia, Australia.
Ivo VlaevSchool of Business, Warwick University, Warwick, UK.
Jason OngSchool of Medicine, Monash University, Melbourne, Victoria, Australia.
Jodie DoddRobinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.
Jennifer CouperRobinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.
Thomas R SullivanSouth Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Jonathan KarnonDiscipline of Public Health, Flinders University, Adelaide, South Australia, Australia.
Nicola SpurrierDiscipline of Paediatrics, Flinders University, Adelaide, South Australia, Australia.
Michael CusackSA Health, South Australian Government, Adelaide, South Australia, Australia.
Dylan MordauntDiscipline of Paediatrics, Flinders University, Adelaide, South Australia, Australia.
Dimi SimatosDiscipline of Paediatrics, Lyell McEwin Hospital, Elizabeth Vale, South Australia, Australia.
Gus DekkerRobinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.
Samantha CarlsonDepartment of Paediatrics, The University of Western Australia, Perth, Western Australia, Australia.
Jane TuckermanDepartment of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
Nicholas WoodDiscipline of Paediatrics, University of Sydney, Sydney, New South Wales, Australia.
Lisa WhopDiscipline of Public Health, Australian National University, Canberra, Australian Capital Territory, Australia.
Helen S MarshallVaccinology and Immunology Research Trials Unit, Women's and Children's Hospital, SA Health, Adelaide, South Australia, Australia. helen.marshall@adelaide.edu.au.
University of Adelaide · AUFlinders University · AUWomen's and Children's Hospital · AUAustralian Government · AUAustralian National University · AUGovernment of South Australia · AULyell McEwin Hospital · AUMonash University · AUMurdoch Children's Research Institute · AUPerth Children's HospitalRoyal Children's Hospital · AUSouth Australian Health and Medical Research Institute · AUUniversity of Sydney · AUUniversity of Warwick · GBUniversity of Western Australia · AU

Funding

National Health and Medical Research Council APP2014684
6 · The paper itself

Abstract

backgroundInfluenza and COVID-19 infections during pregnancy may have serious adverse consequences for women as well as their infants. However, uptake of influenza and COVID-19 vaccines during pregnancy remains suboptimal. This study aims to assess the effectiveness of a multi-component nudge intervention to improve influenza and COVID-19 vaccine uptake among pregnant women.

methodsPregnant women who receive antenatal care at five tertiary hospitals in South Australia, Western Australia and Victoria will be recruited to two separate randomised controlled trials (RCTs). Women will be eligible for the COVID-19 RCT is they have received two or less doses of a COVID-19 vaccine. Women will be eligible for the influenza RCT if they have not received the 2023 seasonal influenza vaccine. Vaccination status at all stages of the trial will be confirmed by the Australian Immunisation Register (AIR). Participants will be randomised (1:1) to standard care or intervention group (n = 1038 for each RCT). The nudge intervention in each RCT will comprise three SMS text message reminders with links to short educational videos from obstetricians, pregnant women and midwives and vaccine safety information. The primary outcome is at least one dose of a COVID-19 or influenza vaccine during pregnancy, as applicable. Logistic regression will compare the proportion vaccinated between groups. The effect of treatment will be described using odds ratio with a 95% CI. DISCUSSION: Behavioural nudges that facilitate individual choices within a complex context have been successfully used in other disciplines to stir preferred behaviour towards better health choices. If our text-based nudges prove to be successful in improving influenza and COVID-19 vaccine uptake among pregnant women, they can easily be implemented at a national level.

trial registrationClinicalTrials.gov Identifier NCT05613751. Registered on November 14, 2022.

Indexed as

COVID-19Influenza, HumanInfluenza VaccinesText MessagingCOVID-19 VaccinesFemaleHumansInfantPregnancyPregnant PeopleRandomized Controlled Trials as TopicVictoriaCOVID-19 VaccinesInfluenza VaccinesCOVID-19InfluenzaPregnancyRandomised controlled trialRCTVaccine

Identifiers

PMID37438776
PMCPMC10339598
OpenAlexW4384069788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.