Evidence map›Paper›PMID 37438532›Full record

ArticleNature2023

Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis.

Fu Yang, Weijia Su, Oliver W Chung, Lauren Tracy, Lu Wang, Dale A Ramsden, Z Z Zhao Zhang

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
29.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Galectin-9Aging cell · 2026
    Article
  9. Article
  10. BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Cytoplasmic circular dsDNA is a key constituent of stress granules.bioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Extrachromosomal Circular DNA and Transposable Elements in Type 2 Diabetes.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Fu Yang *Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-3151-1765
Weijia Su *Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Oliver W ChungDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Lauren TracyDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Lu WangDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-2356-6245
Dale A RamsdenLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-1575-4748
Z Z Zhao ZhangDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. z.z@duke.edu.ORCID 0000-0002-3358-8459
Duke University · USUniversity of North Carolina at Chapel Hill · US

Funding

Structural determinants of Pol theta functionP01CA247773 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Eli Rothenberg · 2020 to 2026
$15.2M
Somatic transposition-mediated genome variegation during development, disease and aging conditionsDP5OD021355 · OD · DUKE UNIVERSITY · PI ZHANG, ZHAO · 2015 to 2019
$2.0M
Regulation, function, and impact of developmental retrotransposon activationR01GM141018 · NIGMS · DUKE UNIVERSITY · PI ZHANG, ZHAO · 2021 to 2024
$1.3M
Biogenesis and function of retrotransposon-derived circular DNAR01GM152423 · NIGMS · DUKE UNIVERSITY · PI ZHANG, ZHAO · 2024 to 2025
$864k
NCI NIH HHS P01 CA247773NIGMS NIH HHS R01 GM141018NIGMS NIH HHS R01 GM152423NIH HHS DP5 OD021355
6 · The paper itself

Abstract

Retrotransposons are highly enriched in the animal genome

Indexed as

DNA, CircularDNA End-Joining RepairDNA ReplicationParasitesRetroelementsAnimalsDNA, Single-StrandedGenomeRNA-Directed DNA PolymeraseRNA, MessengerTemplates, GeneticDNA, CircularDNA, Single-StrandedRetroelementsRNA-Directed DNA PolymeraseRNA, Messenger

Identifiers

PMID37438532
PMCPMC10691919
OpenAlexW4384023928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.