ArticleNature2023
High-throughput Oligopaint screen identifies druggable 3D genome regulators.
Abstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
41 citing papers in PubMed.
- Chromosome painting in plants: history and future perspectives.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Review
- Genome folding and nuclear speckles converge to orchestrate fibroblast activation.Science advances · 2026Article
- Re-establishment of TAD boundary organization during DNA replication.bioRxiv : the preprint server for biology · 2026Article
- Article
- Persistent homology-based multiscale Hi-C analysis uncovers TADs-mediated gene regulation.Scientific reports · 2026Article
- Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption.Molecular cell · 2026Article
- Whole-genome 3D architectural screen reveals modulators of brain DNA structure.bioRxiv : the preprint server for biology · 2026Article
- A genetic screen for modifiers of cohesin clustering identifies regulators of genome folding.Science advances · 2026Article
- Loss of multilevel 3D genome organization during breast cancer progression.Genome research · 2026Article
- High-throughputbioRxiv : the preprint server for biology · 2025Article
- Chromatin looping-based CRISPR screen identifies TLK2 as chromatin loop formation regulator in cancer stemness plasticity.Nature communications · 2025Article
- Persistent chromatin loops shape gene expression plasticity upon stimulation and restimulation of human neurons.bioRxiv : the preprint server for biology · 2025Article
- Learning induces persistent chromatin loops underlying robust gene expression during memory recall.bioRxiv : the preprint server for biology · 2025Article
- Dosage sensitivity of the loop extrusion rate confers tunability to genome folding while creating vulnerability to genetic disruption.bioRxiv : the preprint server for biology · 2025Article
- Revealing the biophysics of lamina-associated domain formation by integrating theoretical modeling and high-resolution imaging.Nature communications · 2025Article
- Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen.bioRxiv : the preprint server for biology · 2025Article
- Wnt signaling activation induces CTCF binding and loop formation atGenome research · 2025Article
- The length and strength of compartmental interactions are modulated by condensin II activity.PLoS genetics · 2025Article
- CTCF/RAD21 organize the ground state of chromatin-nuclear speckle association.Nature structural & molecular biology · 2025Article
- Perturb-tracing enables high-content screening of multi-scale 3D genome regulators.Nature methods · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Daniel S ParkDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5191-1371
Son C NguyenDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-2187-1027
Randi IsenhartDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Parisha P ShahPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wonho KimPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
R Jordan BarnettDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Aditi ChandraDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2053-163X
Jennifer M LuppinoDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2078-7619
Jailynn HarkeDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
May WaiDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Patrick J WalshDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Richard J AbdillDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9565-5832
Rachel YangPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8606-2565
Yemin LanPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sora YoonDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rebecca YunkerDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Masato T KanemakiDepartment of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Shizuoka, Japan.ORCID 0000-0002-7657-1649
Golnaz VahediDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2249-8247
Jennifer E Phillips-CreminsDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-4702-0450
Rajan JainPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1979-044X
Eric F JoyceDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. erjoyce@upenn.edu.ORCID 0000-0002-0418-2804
Funding
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3MEngineering and Imaging 3D genome structure-function dynamics across time scalesU01DK127405 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BLOBEL, GERD A, PHILLIPS-CREMINS, JENNIFER ELIZABETH · 2020 to 2024
$5.7MRegulation of chromatin folding in space and timeR35GM128903 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Eric F. Joyce · 2018 to 2026
$4.2MDeciphering how 3D genome organization orchestrates cardiac cellular identityR35HL166663 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Rajan Jain · 2023 to 2026
$3.5MSingle-cell dissection of chromatin architecture mechanisms connecting pathologic instability and transcriptional silencingU01DA052715 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI JAIN, RAJAN, JOYCE, ERIC F. · 2020 to 2024
$3.1MConnecting 3D genome misfolding to transcriptional silencing in fragile X syndromeR01MH120269 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI PHILLIPS-CREMINS, JENNIFER ELIZABETH · 2019 to 2024
$3.1MElucidating the 3-D epigenetic determinants of activity-dependent gene expression in mammalian neuronsR01NS114226 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI PHILLIPS-CREMINS, JENNIFER ELIZABETH, SHEPHERD, JASON D · 2020 to 2024
$2.3MThe Role of BRD4 in Cardiac SpecificationR01HL139783 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JAIN, RAJAN · 2019 to 2022
$1.6MConnecting 3D genome misfolding to transcriptional silencing in fragile X syndromeR37MH120269 · NIMH · WASHINGTON UNIVERSITY · PI Jennifer Elizabeth Phillips-Cremins · 2025 to 2026
$1.0MEvaluating novel architectural proteins as therapeutic targets for cohesin dysfunctionR21HD107261 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI JOYCE, ERIC F. · 2022 to 2023
$447kElucidating the role of chromatin architecture in the pathophysiology of Cornelia de Lange SyndromeF31HD102084 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI LUPPINO, JENNIFER MARY · 2020 to 2022
$99kInvestigating cohesin regulators to target Cornelia de Lange SyndromeF30HD104360 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI PARK, DANIEL SUNGJOO · 2021 to 2023
$86kNHLBI NIH HHS R01 HL139783NICHD NIH HHS F30 HD104360NICHD NIH HHS F31 HD102084NICHD NIH HHS R21 HD107261NIDA NIH HHS U01 DA052715NIDDK NIH HHS U01 DK127405NIGMS NIH HHS R35 GM128903NIGMS NIH HHS T32 GM008216NIMH NIH HHS R01 MH120269NIMH NIH HHS R37 MH120269NINDS NIH HHS R01 NS114226
Abstract
The human genome functions as a three-dimensional chromatin polymer, driven by a complex collection of chromosome interactions
Indexed as
ChromatinChromosome PositioningChromosomes, HumanGenome, HumanGlycogen Synthase KinasesHigh-Throughput Screening AssaysSingle-Cell AnalysisCohesinsDNAHumansInterphaseReproducibility of ResultsRNASignal TransductionChromatinCohesinsDNAGlycogen Synthase KinasesGSK3A protein, humanRNA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.