ArticleNature2023
Spatially resolved multiomics of human cardiac niches.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 249 papers, 1 of them a synthesis that pooled it.
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249citing papers in PubMed, 1 pooled it
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Who cites it
249 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.Nature communications · 2025Pooled it
- An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon-like peptide-1 and glucagon receptor in healthy subjects.British journal of clinical pharmacology · 2026Trial
- Exenatide and glucagon co-infusion increases myocardial glucose uptake and improves markers of diastolic dysfunction in adults with type 2 diabetes.Scientific reports · 2025Trial
- GRAIL-heart: A graph attention network for inferring ligand-receptor interactions in spatial transcriptomics.MethodsX · 2026Article
- BMAL1 in cardiovascular diseases: Molecular mechanisms, circadian regulation and translational perspectives (Review).Molecular medicine reports · 2026Review
- Article
- Cardiac lymphatic dysfunction and repair in cardiovascular disease.Nature reviews. Cardiology · 2026Review
- Single-Nucleus Transcriptomic Atlas Reveals Disease-Associated Cellular States in Human Glomerular Diseases.Kidney international reports · 2026Article
- Article
- Age-associated loss of lymphatic vessels promotes cardiac inflammation.Nature cardiovascular research · 2026Article
- The ADP-ribosyltransferases 3 (ART3) is a novel suppressor of pathological cardiac hypertrophy by ribosylating ITGA7.Acta pharmaceutica Sinica. B · 2026Article
- Spatially guided in vivo single-cell functional genomics of postnatal heart.Nature cardiovascular research · 2026Article
- Reversing the pipeline: a 'human-first' multi-omics approach to cardiovascular discovery.Experimental & molecular medicine · 2026Review
- BDNF/TrkB Signaling in Intracardiac Ganglia Modulates Cardiac Parasympathetic Tone.International journal of molecular sciences · 2026Article
- Cardiac fibroblast diversity in HFpEF: states, niches, interorgan drivers and targets.Nature reviews. Cardiology · 2026Review
- Cardiac immunity and heart repair: Mechanism, challenge, and future direction.Chinese medical journal · 2026Review
- CellRank: consistent and data view agnostic fate mapping for single-cell genomics.Nature protocols · 2026Review
- The multi-modal digital heart: From future perspective to challenges.Journal of translational internal medicine · 2026Article
- Decoding Cardiac Development and Maturation at Single-Cell and Spatial Transcriptomic Resolution.Circulation research · 2026Review
- Human genetics across levels of biological organization.Nature reviews. Genetics · 2026Review
189 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
38 authors.
Kazumasa Kanemaru *Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0003-0018-8966
James Cranley *Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-0408-5801
Daniele MuraroWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Antonio M A MirandaNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0003-4281-614X
Siew Yen HoCardiac Morphology Unit, Royal Brompton Hospital and Imperial College London, London, UK.ORCID 0000-0002-3913-5637
Anna Wilbrey-ClarkWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Jan Patrick PettWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Krzysztof PolanskiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-2586-9576
Laura RichardsonWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-8075-3816
Monika LitvinukovaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Natsuhiko KumasakaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-3557-0375
Yue QinNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-9009-6899
Zuzanna JablonskaNational Heart and Lung Institute, Imperial College London, London, UK.
Claudia I SemprichWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-2446-9028
Lukas MachNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0001-7824-4468
Monika DabrowskaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Nathan RichozMolecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge, UK.
Liam BoltWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0001-7293-0774
Lira MamanovaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0003-1463-8622
Rakeshlal KapugeWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0009-0001-3394-0387
Sam N BarnettNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-8968-4319
Shani PereraWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Carlos Talavera-LópezWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0001-8590-2393
Ilaria MulasWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0003-2556-9685
Krishnaa T MahbubaniDepartment of Surgery, University of Cambridge, and Cambridge Biorepository for Translational Medicine, NIHR Cambridge Biomedical Centre, Cambridge, UK.ORCID 0000-0002-1327-2334
Liz TuckWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Lu WangTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-4418-8602
Margaret M HuangDepartment of Surgery, University of Cambridge, and Cambridge Biorepository for Translational Medicine, NIHR Cambridge Biomedical Centre, Cambridge, UK.
Martin PreteWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-5946-821X
Sophie PritchardWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
John DarkTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-4727-6085
Kourosh Saeb-ParsyDepartment of Surgery, University of Cambridge, and Cambridge Biorepository for Translational Medicine, NIHR Cambridge Biomedical Centre, Cambridge, UK.ORCID 0000-0002-0633-3696
Minal PatelWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Menna R ClatworthyWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Norbert HübnerMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.ORCID 0000-0002-1218-6223
Rasheda A ChowdhuryNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0003-4204-1014
Michela NosedaNational Heart and Lung Institute, Imperial College London, London, UK. m.noseda@imperial.ac.uk.ORCID 0000-0002-9553-5029
Sarah A TeichmannWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. st9@sanger.ac.uk.ORCID 0000-0002-6294-6366
Funding
British Heart Foundation FS/CRTF/23/24444
Abstract
The function of a cell is defined by its intrinsic characteristics and its niche: the tissue microenvironment in which it dwells. Here we combine single-cell and spatial transcriptomics data to discover cellular niches within eight regions of the human heart. We map cells to microanatomical locations and integrate knowledge-based and unsupervised structural annotations. We also profile the cells of the human cardiac conduction system
Indexed as
Cellular MicroenvironmentHeartMultiomicsMyocardiumCell CommunicationFibroblastsForkhead Transcription FactorsGlutamic AcidHeart Conduction SystemHumansIon ChannelsMyocytes, CardiacNeurogliaPericardiumPlasma CellsReceptors, G-Protein-CoupledForkhead Transcription FactorsFOXP2 protein, humanGlutamic AcidIon ChannelsReceptors, G-Protein-Coupled
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.