ArticleNature2023
Mast cells link immune sensing to antigen-avoidance behaviour.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
20.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 122 citations in OpenAlex.
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Developments in Mast Cell Research.The Journal of allergy and clinical immunology · 2026Review
- CaClinical and experimental pharmacology & physiology · 2026Article
- Review
- Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine.Nature chemical biology · 2026Article
- Eosinophil-epithelial interactions mediate protective intestinal remodeling during food allergy.bioRxiv : the preprint server for biology · 2026Article
- Synthetic food pigment sunset yellow potentiates food allergy via immune dysregulation and intestinal barrier dysfunction.NPJ science of food · 2026Article
- Effects of High-Inorganic-Phosphorus Diet on Intestinal Mucosal Injury and Immune Alteration in Mice.Nutrients · 2026Article
- Distinct phosphoinositide signatures orchestrate FcεRI versus MRGPRX2 mast cell secretion.iScience · 2026Article
- Adenosine-Specific Transcriptional Programs in Murine Connective Tissue-Type Mast Cells.ACS pharmacology & translational science · 2026Article
- Early life group 2 innate lymphoid cells in health and disease.Molecular and cellular pediatrics · 2026Review
- Immune microenvironment of infantile hemangioma: cellular dynamics, molecular networks, and emerging immunomodulatory strategies.Frontiers in immunology · 2026Review
- Mast cell extracellular granules are bioactive condensates driven by heparin and polyamine.bioRxiv : the preprint server for biology · 2025Article
- Development of an intestinal allergy model to evaluate the initial introduction of infant rice cereal.NPJ science of food · 2025Article
- Review
- Unraveling cysteinyl leukotrienes and their receptors in inflammation through the brain-gut-lung axis.Virulence · 2025Review
- Food allergy: begin at the skin, end at the mast cell?Nature reviews. Immunology · 2025Review
- Neuronal detection triggers systemic digestive shutdown in response to adverse food sources ineLife · 2025Article
- Sensory signals for nausea.Trends in neurosciences · 2025Review
- Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
24 authors at 7 institutions in 5 countries.
Thomas Plum *Division for Cellular Immunology, German Cancer Research Center, Heidelberg, Germany. t.plum@dkfz.de.ORCID 0000-0002-7811-4476
Rebecca Binzberger *Division for Cellular Immunology, German Cancer Research Center, Heidelberg, Germany.
Robin ThieleDivision for Cellular Immunology, German Cancer Research Center, Heidelberg, Germany.
Fuwei ShangDivision for Cellular Immunology, German Cancer Research Center, Heidelberg, Germany.
Daniel PostrachDivision for Cellular Immunology, German Cancer Research Center, Heidelberg, Germany.
Candice FungLaboratory for Enteric NeuroScience Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium.ORCID 0000-0002-4277-3664
Marina ForteaLaboratory for Enteric NeuroScience Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium.
Nathalie StakenborgLaboratory for Intestinal Neuroimmune Interactions, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium.ORCID 0000-0002-6229-0045
Zheng WangLaboratory for Intestinal Neuroimmune Interactions, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium.
Anke Tappe-TheodorPharmacology Institute, Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-9343-7580
Tanja PothCenter for Model System and Comparative Pathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Duncan A A MacLarenDepartment of Clinical Neurobiology of the Medical Faculty of Heidelberg University and German Cancer Research Center, Heidelberg, Germany.
Guy BoeckxstaensLaboratory for Intestinal Neuroimmune Interactions, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium.ORCID 0000-0001-8267-5797
Rohini KunerPharmacology Institute, Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-3333-9129
Claudia PitzerInterdisciplinary Neurobehavioral Core, Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-7663-1031
Hannah MonyerDepartment of Clinical Neurobiology of the Medical Faculty of Heidelberg University and German Cancer Research Center, Heidelberg, Germany.
Cuiyan XinDivision of Renal Medicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Joseph V BonventreDivision of Renal Medicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7144-386X
Satoshi TanakaLaboratory of Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.ORCID 0000-0002-3468-7694
David VoehringerDepartment of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000-0001-6650-0639
Pieter Vanden BergheLaboratory for Enteric NeuroScience Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium.ORCID 0000-0002-0009-2094
Jessica StridDepartment of Immunology and Inflammation, Imperial College London, London, UK.ORCID 0000-0003-3690-2201
Thorsten B FeyerabendDivision for Cellular Immunology, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-1205-6568
Hans-Reimer RodewaldDivision for Cellular Immunology, German Cancer Research Center, Heidelberg, Germany. hr.rodewald@dkfz.de.ORCID 0000-0002-1452-3828
German Cancer Research Center · DEKU Leuven · BEHeidelberg University · DEBrigham and Women's Hospital · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEImperial College London · GBKyoto Pharmaceutical University · JP
Funding
KIDNEY INJURY MOLECULE-1 IN EPITHELIAL REPAIRR01DK072381 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2005 to 2025
$8.6MMechanisms of Ischemic Kidney Injury and RepairR01DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JOSEPH VINCENT BONVENTRE · 1987 to 2026
$6.2MMechanisms of Ischemic Kidney Injury and RepairR37DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1993 to 2021
$5.2MNIDDK NIH HHS R01 DK039773NIDDK NIH HHS R01 DK072381NIDDK NIH HHS R37 DK039773
Abstract
The physiological functions of mast cells remain largely an enigma. In the context of barrier damage, mast cells are integrated in type 2 immunity and, together with immunoglobulin E (IgE), promote allergic diseases. Allergic symptoms may, however, facilitate expulsion of allergens, toxins and parasites and trigger future antigen avoidance
Indexed as
AllergensAvoidance LearningHypersensitivityMast CellsAnimalsCytokinesImmunity, InnateImmunity, MucosalImmunoglobulin EIntestine, SmallLeukotrienesMiceStomachTh2 CellsVagotomyAllergensCytokinesImmunoglobulin ELeukotrienes
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.