Evidence map›Paper›PMID 37438431›Full record

ReviewNature reviews. Neurology2023

The 5-HT

Dimos D Mitsikostas, Christian Waeber, Margarita Sanchez-Del-Rio, Bianca Raffaelli, Håkan Ashina, Antoinette Maassen van den Brink, Anna Andreou, Patricia Pozo-Rosich, Alan Rapoport, Messoud Ashina and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. International journal of molecular sciences · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Cannabinoids rescue migraine symptoms caused by central CGRP administration in mice.Cephalalgia : an international journal of headache · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024
    Review
  17. Observational
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 8 countries.

Dimos D Mitsikostas1st Neurology Department, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. dmitsikostas@uoa.gr.ORCID 0000-0002-4691-3388
Christian WaeberSchool of Pharmacy, University College Cork, Cork, Ireland.ORCID 0000-0001-6078-0027
Margarita Sanchez-Del-RioNeurology Department, Clinica Universidad de Navarra, Madrid, Spain.ORCID 0000-0001-7724-2890
Bianca RaffaelliDepartment of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Håkan AshinaDepartment of Neurology, Danish Headache Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-6268-727X
Antoinette Maassen van den BrinkDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, Netherlands.ORCID 0000-0001-7176-126X
Anna AndreouWolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Patricia Pozo-RosichNeurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Alan RapoportDepartment of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0002-6311-8562
Messoud AshinaDepartment of Neurology, Danish Headache Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Michael A MoskowitzDepartments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Copenhagen University Hospital · DKBeth Israel Deaconess Medical Center · USClinica Universidad de Navarra · ESErasmus MC · NLHarvard University · USKing's College London · GBNational and Kapodistrian University of Athens · GRUniversitat Autònoma de Barcelona · ESUniversity College Cork · IEUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine is a leading cause of disability in more than one billion people worldwide, yet it remains universally underappreciated, even by individuals with the condition. Among other shortcomings, current treatments (often repurposed agents) have limited efficacy and potential adverse effects, leading to low treatment adherence. After the introduction of agents that target the calcitonin gene-related peptide pathway, another new drug class, the ditans - a group of selective serotonin 5-HT

Indexed as

Migraine DisordersReceptors, SerotoninCalcitonin Gene-Related PeptideCalcitonin Gene-Related Peptide Receptor AntagonistsHumansReceptor, Serotonin, 5-HT1FCalcitonin Gene-Related PeptideCalcitonin Gene-Related Peptide Receptor AntagonistsReceptor, Serotonin, 5-HT1FReceptors, Serotonin

Identifiers

PMID37438431
OpenAlexW4384030419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.