ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2023
Associations between childhood ethnoracial minority density, cortical thickness, and social engagement among minority youth at clinical high-risk for psychosis.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Neighborhood Characteristics and Psychosis Risk Across Development.Schizophrenia research · 2026Article
- Social withdrawal and hippocampal volume among adolescents at clinical high risk for psychosis and healthy comparisons: The moderating role of neighborhood residential stability.Schizophrenia research · 2026Article
- Neighborhood opportunity, white matter, and cognition in a large pediatric neuroimaging study.Translational psychiatry · 2026Article
- The moderating role of lifetime social engagement on the relationship between C-reactive protein and negative symptoms among young adults at clinical high risk for psychosis.Brain, behavior, and immunity · 2025Article
- Exposure profiles of social-environmental neighborhood factors and persistent distressing psychotic-like experiences across four years among young adolescents in the US.Psychological medicine · 2025Article
- Brain health in ethnically minority youth at risk for psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
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Authors and funding
17 authors.
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Abstract
An ethnoracial minority density (EMD) effect in studies of psychotic spectrum disorders has been observed, whereby the risk of psychosis in ethnoracial minority group individuals is inversely related to the proportion of minorities in their area of residence. The authors investigated the relationships among area-level EMD during childhood, cortical thickness (CT), and social engagement (SE) in clinical high risk for psychosis (CHR-P) youth. Data were collected as part of the North American Prodrome Longitudinal Study. Participants included 244 ethnoracial minoritized (predominantly Hispanic, Asian and Black) CHR-P youth and ethnoracial minoritized healthy controls. Among youth at CHR-P (n = 164), lower levels of EMD during childhood were associated with reduced CT in the right fusiform gyrus (adjusted β = 0.54; 95% CI 0.17 to 0.91) and right insula (adjusted β = 0.40; 95% CI 0.05 to 0.74). The associations between EMD and CT were significantly moderated by SE: among youth with lower SE (SE at or below the median, n = 122), lower levels of EMD were significantly associated with reduced right fusiform gyrus CT (adjusted β = 0.72; 95% CI 0.29 to 1.14) and reduced right insula CT (adjusted β = 0.57; 95% CI 0.18 to 0.97). However, among those with greater SE (n = 42), the associations between EMD and right insula and fusiform gyrus CT were not significant. We found evidence that lower levels of ethnic density during childhood were associated with reduced cortical thickness in regional brain regions, but this association may be buffered by greater levels of social engagement.
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