ArticleScientific reports2023
Solubility of hesperidin drug in aqueous biodegradable acidic choline chloride-based deep eutectic solvents.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Effects of some surface active ionic liquids on the aqueous solubility, thermodynamic properties and fluorescence behavior of drug diclofenac sodium.Scientific reports · 2026Article
- Natural phytochemical-based strategies for antibiofilm applications.Chinese medicine · 2025Review
- Extraction of Chlorogenic Acid Using Single and Mixed Solvents.Molecules (Basel, Switzerland) · 2025Article
- Solubility of mesalazine in pseudo-binary mixtures of choline chloride/ethylene glycol deep eutectic solvent and water at 293.15 K to 313.15 K.BMC chemistry · 2023Article
- Upcycling Wool Waste into Keratin Gel-Based Nanofibers Using Deep Eutectic Solvents.Gels (Basel, Switzerland) · 2023Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Important efforts have been made over the past years to improve the drug acts, which leads to the discovery of novel drug preparations and delivery systems. The selection of suitable green solvents for novel drug discovery and drug delivery depends on a molecular-level understanding of the interaction between drug molecules and the solvents. Deep eutectic solvents (DESs) are already used in sustainable extraction methods of natural products for their very high solvent power, high chemical and thermal stability, non-toxicity, and non-flammable. The thermodynamic investigation provides deep and complete knowledge of interactions and the choice of appropriate and suitable production compounds in pharmaceutical fields. Particularly, the analysis of drugs+DESs in aqueous media is a central issue in many types of research. This research is aimed to determine hesperidin (HES) solubility in water and DES solvents [choline chloride/citric acid (ChCl/CA), choline chloride/oxalic acid (ChCl/OA), choline chloride/malonic acid (ChCl/MA), and choline chloride/lactic acid (ChCl/LA)] at temperature range (298.15-313.15 K). Furthermore, the measured solubility data of HES in studied aqueous DESs solutions was fitted by models of Van't Hoff-Jouyban-Acree and Modified Apelblat-Jouyban-Acree. Finally, the Hansen solubility parameters as thermodynamic aspect for analyzing the dissolution processes for the four investigated aqueous DESs solutions were estimated.
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