Evidence map›Paper›PMID 37438138›Full record

ArticleInternal medicine (Tokyo, Japan)2024

Improvement of Light Chain Proximal Tubulopathy without Crystals in IgGλ-type Monoclonal Gammopathy of Undetermined Significance Using Bortezomib and Dexamethasone.

Tomohisa Tsuyuki, Tadashi Uramatsu, Masatoshi Shimizu, Takuma Ishi, Kiyokazu Tsuji, Jun Nakashima, Eisuke Katafuchi, Toshiyuki Nakayama, Noriko Uesugi, Kumiko Muta and 1 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Tomohisa TsuyukiDepartment of Nephrology, Nagasaki University Hospital, Japan.
Tadashi UramatsuDepartment of Nephrology, JCHO Isahaya General Hospital, Japan.
Masatoshi ShimizuDepartment of Nephrology, Nagasaki University Hospital, Japan.
Takuma IshiDepartment of Nephrology, Nagasaki University Hospital, Japan.
Kiyokazu TsujiDepartment of Nephrology, JCHO Isahaya General Hospital, Japan.
Jun NakashimaDepartment of Hematology, JCHO Isahaya General Hospital, Japan.
Eisuke KatafuchiDepartment of Pathology, University of Occupational and Environmental Health School, Japan.
Toshiyuki NakayamaDepartment of Pathology, University of Occupational and Environmental Health School, Japan.
Noriko UesugiDepartment of Pathology, Fukuoka University Hospital, Japan.
Kumiko MutaDepartment of Nephrology, Nagasaki University Hospital, Japan.
Tomoya NishinoDepartment of Nephrology, Nagasaki University Hospital, Japan.
Nagasaki University Hospital · JPUniversity of Occupational and Environmental Health Japan · JPFukuoka University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 70-year-old woman with acute kidney injury, a high serum Creatinine (Cr) level (3.91 mg/dL), and proteinuria (protein/Cr ratio 1.59 g/gCr) was admitted. Serum IgG λ-type and urinary λ-type M proteins were observed. A bone marrow examination indicated monoclonal gammopathy of undetermined significance (MGUS). A renal biopsy showed distended proximal tubular cells, and immunofluorescence identified tissue positive for proximal tubular cell λ light chains. Electron microscopy identified fibril-like structures in the lysosomes. The patient was diagnosed with light chain proximal tubulopathy without crystals in IgG λ-type MGUS and treated with bortezomib and dexamethasone therapy, which improved her renal function.

Indexed as

Kidney DiseasesMonoclonal Gammopathy of Undetermined SignificanceParaproteinemiasAgedBortezomibDexamethasoneFemaleHumansImmunoglobulin GBortezomibDexamethasoneImmunoglobulin Glight chain proximal tubulopathy without crystalsmonoclonal gammopathy of renal significancemonoclonal gammopathy of undetermined significanceparaprotein-related kidney disease

Identifiers

PMID37438138
PMCPMC10982019
OpenAlexW4383900010

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.