Evidence map›Paper›PMID 37438116›Full record

ArticleThe Journal of veterinary medical science2023

Identification of a syncytin gene in a non-rodent laboratory mammal, Suncus murinus.

Miki Suzuki, Akihiro Nakamura, Yu Matsumoto, Woojin Kang, Minoru Ichinose, Natsuko Kawano, Mitsutoshi Yamada, Miyuki Shindo, Daiki Katano, Takako Saito and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Miki SuzukiDepartment of Reproductive Biology, National Research Institute for Child Health and Development, Tokyo, Japan.
Akihiro NakamuraDepartment of Microbiology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
Yu MatsumotoDepartment of Life Sciences, School of Agriculture, Meiji University, Kanagawa, Japan.
Woojin KangDepartment of Reproductive Biology, National Research Institute for Child Health and Development, Tokyo, Japan.
Minoru IchinoseDepartment of Reproductive Biology, National Research Institute for Child Health and Development, Tokyo, Japan.
Natsuko KawanoDepartment of Life Sciences, School of Agriculture, Meiji University, Kanagawa, Japan.
Mitsutoshi YamadaDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Miyuki ShindoDivision of Laboratory Animal Resources, National Research Institute for Child Health and Development, Tokyo, Japan.
Daiki KatanoDepartment of Life Sciences, School of Agriculture, Meiji University, Kanagawa, Japan.
Takako SaitoDepartment of Applied Life Sciences, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan.
Yuichirou HaradaDepartment of Molecular Pathology, Tokyo Medical University, Tokyo, Japan.
Mami MiyadoDepartment of Food and Nutrition, Beppu University, Oita, Japan.
Kenji MiyadoDepartment of Reproductive Biology, National Research Institute for Child Health and Development, Tokyo, Japan.
National Center For Child Health and Development · JPMeiji University · JPBeppu University · JPKeio University · JPSaitama Medical University · JPShizuoka University · JPTokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An endogenous retrovirus-derived membrane protein, syncytin (SYN), contributes to placental function via trophoblast fusion. Multinuclear trophoblasts (syncytiotrophoblasts) physically and functionally mediate the interaction between fetal and maternal vessels in various ways. Suncus murinus (suncus) is a small mammalian species with a pregnancy duration of approximately 30 days, 1.5 times longer than mice. However, the molecular basis for the longer pregnancy duration is unknown. In this study, we first isolated two genes that encoded putative SYN proteins expressed in the suncus placenta, which were named syncytin-1-like proteins 1 and 2 (SYN1L1 and SYN1L2). When their expression vectors were introduced into cultured cells, suncus SYN1L2 was found to be active in cell fusion. Moreover, the SYN1L2 protein was homologous to a SYN1-like protein identified in greater mouse-eared bats (bat SYN1L) and was structurally compared with bat SYN1L and other SYN proteins, implying the presence of structural features of the SYN1L2 protein.

Indexed as

ChiropteraPregnancy ProteinsAnimalsFemaleGene Products, envPlacentaPregnancyShrewsGene Products, envPregnancy Proteinssyncytinnon-rodent mammalplacentasuncussyncytin

Identifiers

PMID37438116
PMCPMC10539813
OpenAlexW4383900228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.