Evidence map›Paper›PMID 37437654›Full record

ArticleGastroenterologia y hepatologia2024

Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway.

Yanghui Bi, Liping Zhang, Yan Song, Lijun Sun, Michael W Mulholland, Yue Yin, Weizhen Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterologia y hepatologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yanghui BiSchool of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Liping ZhangDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA.
Yan SongFirst Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Lijun SunSchool of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Michael W MulhollandDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA.
Yue YinDepartment of Pharmacology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, China. Electronic address: yueyin@bjmu.edu.cn.
Weizhen ZhangSchool of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA. Electronic address: weizhenzhang@bjmu.edu.cn.
Peking University · CNUniversity of Michigan–Ann Arbor · USThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3M
The mTOR-ETV5 signaling in gastric X/A like cells and its role in hepatic lipid metabolism and steatosisR01DK129360 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEELEY, RANDY J · 2021 to 2024
$2.4M
R-spondin1-LGR4 Signaling and Ischemia/Reperfusion Injury in Steatotic LiverR01DK110273 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MULHOLLAND, MICHAEL W., ZHANG, WEIZHEN · 2017 to 2021
$2.1M
Gastric X/A Like Cells in Health and DiseasesR01DK112755 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEELEY, RANDY J · 2018 to 2022
$1.6M
NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK110273NIDDK NIH HHS R01 DK112755NIDDK NIH HHS R01 DK129360
6 · The paper itself

Abstract

backgroundThe leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4) plays an important role in stem cell differentiation, organ development and cancer. Whether LGR4 affects the progression of hepatocellular carcinoma (HCC) remains unknown. This study aimed to reveal the role of LGR4 in HCC.

methodsClinical samples of HCC were collected to assess the expression of LGR4 and its correlation with patients' clinical characteristics. The expression level of LGR4 in HCC cells was altered by pharmacological and genetic methods, and the role of LGR4 in HCC progression was analyzed by in vivo and in vitro assays. HCC was induced by diethylnitrosamine (DEN) and carbon tetrachloride (CCl

resultsLGR4 expression was up-regulated in HCC samples, and its expression level was positively correlated with tumor size, microvascular invasion (MVI), TNM stage and pathological differentiation grade of HCC patients. In the mouse HCC model induced by DEN+CCl

conclusionsLGR4 promotes HCC progression via Wnt/β-catenin signaling pathway.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsbeta CateninCell DifferentiationDisease Models, AnimalHumansMiceReceptors, G-Protein-CoupledWnt Signaling Pathwaybeta CateninLGR4 protein, humanLGR4 protein, mouseReceptors, G-Protein-CoupledCaracterísticas similares a las células madreCarcinoma hepatocelularEfecto warburgEpithelial–mesenchymal transitionHepatocellular carcinomaReceptor de acoplamiento de proteínas G de secuencia repetida 4Roof slab-specific sponge 2R-spondin2Stem cell-like propertiesThe leucine-rich repeat-containing G-protein-coupled receptor 4Transformación epitelial-estromalWarburg effect

Identifiers

PMID37437654
PMCPMC10863972
OpenAlexW4383745146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.