ArticleNature2023
Immune sensing of food allergens promotes avoidance behaviour.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
23.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 142 citations in OpenAlex.
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Developments in Mast Cell Research.The Journal of allergy and clinical immunology · 2026Review
- Review
- Dietary allergen promotes sex-specific leukocyte trafficking and alters the brain immune cell populations in subclinically sensitized mice.Brain, behavior, and immunity · 2026Article
- Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine.Nature chemical biology · 2026Article
- Epigenetic mechanisms of inflammatory memory in the central nervous system.Nature immunology · 2026Review
- Eosinophil-epithelial interactions mediate protective intestinal remodeling during food allergy.bioRxiv : the preprint server for biology · 2026Article
- Structural immunity: immune cells as architects of tissue barriers.Nature reviews. Immunology · 2026Review
- Adenosine-Specific Transcriptional Programs in Murine Connective Tissue-Type Mast Cells.ACS pharmacology & translational science · 2026Article
- Improved Bin-Based Basophil Activation Test Facilitates Comparison of Wheat Allergy and Tolerance in Children and Adults.International journal of molecular sciences · 2026Article
- Article
- Early life group 2 innate lymphoid cells in health and disease.Molecular and cellular pediatrics · 2026Review
- Developmental PBDE exposure persistently impairs mast cell function in vivo and drives sex-specific morphological and transcriptional changes in bone marrow-derived mast cells.Environmental research · 2026Article
- Neural mechanisms of food preference and reward processing: a review of multifaceted influencing factors and intervention strategies.Frontiers in nutrition · 2026Review
- Mast cell extracellular granules are bioactive condensates driven by heparin and polyamine.bioRxiv : the preprint server for biology · 2025Article
- Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states.Cell · 2025Article
- Development of an intestinal allergy model to evaluate the initial introduction of infant rice cereal.NPJ science of food · 2025Article
- Review
- Brain-immune interactions generate pathogen-specific sickness states.bioRxiv : the preprint server for biology · 2025Article
- Unraveling cysteinyl leukotrienes and their receptors in inflammation through the brain-gut-lung axis.Virulence · 2025Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Update of
Authors and funding
14 authors at 4 institutions in 4 countries.
Esther B Florsheim *Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. esther.florsheim@asu.edu.ORCID 0000-0002-5889-7442
Nathaniel D Bachtel *Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2631-2243
Jaime L CullenDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Bruna G C LimaSchool of Life Sciences, Arizona State University, Tempe, AZ, USA.
Mahdieh GodazgarDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Fernando CarvalhoDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Carolina P ChatainDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Marcelo R ZimmerDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Cuiling ZhangDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Gregory GautierCentre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France.
Pierre LaunayCentre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France.
Andrew WangDepartment of Medicine (Rheumatology, Allergy & Immunology), Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6951-8081
Marcelo O DietrichDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-9781-2221
Ruslan MedzhitovDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. ruslan.medzhitov@yale.edu.ORCID 0000-0002-7021-2012
Yale University · USCentre National de la Recherche Scientifique · FRHoward Hughes Medical Institute · USUniversidade de São Paulo · BR
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MDissecting How Xenobiotics Act as Adjuvants for Oral Allergic SensitizationR01AI162645 · NIAID · YALE UNIVERSITY · PI Andrew Wang · 2021 to 2026
$3.6MThe Role of the Adrb3/IL6 Axis in the Impact of Psychosocial Stress on Lupus PathogenesisR01AR080104 · NIAMS · YALE UNIVERSITY · PI Andrew Wang · 2022 to 2026
$2.2MRole of GDF15 in the Regulation of Host Tolerance to InflammationR01AI144152 · NIAID · YALE UNIVERSITY · PI MEDZHITOV, RUSLAN · 2019 to 2023
$2.1MMast cell regulation of food allergen induced malaise through GDF15-GFRAL signalingF30AI174787 · NIAID · YALE UNIVERSITY · PI BACHTEL, NATHANIEL DALE · 2023 to 2025
$121kNCATS NIH HHS UL1 TR001863NIAID NIH HHS F30 AI174787NIAID NIH HHS R01 AI144152NIAID NIH HHS R01 AI162645NIAMS NIH HHS R01 AR080104
Abstract
In addition to its canonical function of protection from pathogens, the immune system can also alter behaviour
Indexed as
AllergensAvoidance LearningFood HypersensitivityAnimalsCentral Amygdaloid NucleusCysteineDisease Models, AnimalGrowth Differentiation Factor 15Immunoglobulin EIntestinesLeukotrienesMast CellsMiceMice, Inbred BALB CMice, Inbred C57BLParabrachial NucleusAllergensCysteinecysteinyl-leukotrieneGdf15 protein, mouseGrowth Differentiation Factor 15Immunoglobulin ELeukotrienes
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.