Evidence map›Paper›PMID 37436794›Full record

ArticleJMIR research protocols2023

Feasibility of a Home-Based Cognitive-Physical Exercise Program in Patients With Chronic Obstructive Pulmonary Disease: Protocol for a Feasibility and Pilot Randomized Controlled Trial.

Dmitry Rozenberg, Josh Shore, Encarna Camacho Perez, Sahar Nourouzpour, Megha Ibrahim Masthan, Daniel Santa Mina, Jennifer L Campos, Ella Huszti, Robin Green, Mohammad Hashim Khan and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JMIR research protocols, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05140226 (Feasibility of a Home-Based Cognitive-Physical Exercise Program in Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05140226 nacompletednot on this map

Feasibility of a Home-Based Cognitive-Physical Exercise Program in Chronic Obstructive Pulmonary Disease (COPD) Patients: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorUniversity Health Network, TorontoRan2022 to 2025Enrolled24ConditionsPulmonary Disease, Chronic ObstructiveArmsPhysical Training, Cognitive-Physical Training
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Dmitry RozenbergRespirology and Lung Transplantation, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-8786-9152
Josh ShoreDivision of Respirology, University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-9060-2173
Encarna Camacho PerezDivision of Respirology, University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-0314-0140
Sahar NourouzpourDivision of Respirology, University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-9297-3042
Megha Ibrahim MasthanDivision of Respirology, University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0009-0003-1393-4523
Daniel Santa MinaFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-4361-1656
Jennifer L CamposToronto Rehabilitation Institute (KITE), University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-7054-3946
Ella HusztiBiostatistics Research Unit, University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-0169-4895
Robin GreenToronto Rehabilitation Institute (KITE), University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-9451-3963
Mohammad Hashim KhanDivision of Respirology, University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-7798-3303
Ambrose LauTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0009-0003-8942-0721
David GoldKrembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-9802-0362
Matthew B StanbrookTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-8873-1497
W Darlene ReidToronto Rehabilitation Institute (KITE), University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-9980-8699
University Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is a progressive condition associated with physical and cognitive impairments contributing to difficulty in performing activities of daily living (ADLs) that require dual tasking (eg, walking and talking). Despite evidence showing that cognitive decline occurs among patients with COPD and may contribute to functional limitations and decreased health-related quality of life (HRQL), pulmonary rehabilitation continues to focus mainly on physical training (ie, aerobic and strength exercises). An integrated cognitive and physical training program compared to physical training alone may be more effective in increasing dual-tasking ability among people living with COPD, leading to greater improvements in performance of ADLs and HRQL.

objectiveThe aims of this study are to evaluate the feasibility of an 8-week randomized controlled trial of home-based, cognitive-physical training versus physical training for patients with moderate to severe COPD and derive preliminary estimates of cognitive-physical training intervention efficacy on measures of physical and cognitive function, dual task performance, ADLs, and HRQL.

methodsA total of 24 participants with moderate to severe COPD will be recruited and randomized into cognitive-physical training or physical training. All participants will be prescribed an individualized home physical exercise program comprising 5 days of moderate-intensity aerobic exercise (30-50 minutes/session) and 2 days of whole-body strength training per week. The cognitive-physical training group will also perform cognitive training for approximately 60 minutes, 5 days per week via the BrainHQ platform (Posit Science Corporation). Participants will meet once weekly with an exercise professional (via videoconference) who will provide support by reviewing the progression of their training and addressing any queries. Feasibility will be assessed through the recruitment rate, program adherence, satisfaction, attrition, and safety. The intervention efficacy regarding dual task performance, physical function, ADLs, and HRQL will be evaluated at baseline and at 4 and 8 weeks. Descriptive statistics will be used to summarize intervention feasibility. Paired 2-tailed t tests and 2-tailed t tests will be used to compare the changes in the outcome measures over the 8-week study period within and between the 2 randomized groups, respectively.

resultsEnrollment started in January 2022. It is estimated that the enrollment period will be 24 months long, with data collection to be completed by December 2023.

conclusionsA supervised home-based cognitive-physical training program may be an accessible intervention to improve dual-tasking ability in people living with COPD. Evaluating the feasibility and effect estimates is a critical first step to inform future clinical trials evaluating this approach and its effects on physical and cognitive function, ADL performance, and HRQL.

trial registrationClinicalTrials.gov NCT05140226; https://clinicaltrials.gov/ct2/show/NCT05140226. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/48666.

Indexed as

chronic obstructivecognitive trainingphysical exercisepilot studypulmonary diseaserandomized controlled trialtelerehabilitation

Identifiers

PMID37436794
PMCPMC10372770
OpenAlexW4378217843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.