Evidence map›Paper›PMID 37436539›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2023

Pentoxifylline and tocopherol as prophylaxis for osteonecrosis of the jaw due to bone-modifying agents in patients with cancer submitted to tooth extraction: a case series.

Jackeline Mayara Inácio Magalhães, Fabiana Moura da Motta Silveira, Luciana Silva Regueira, Douglas Felipe de Lima E Silva, Samuel Rodrigo de Andrade Veras, Maria Júlia Gonçalves de Mello

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jackeline Mayara Inácio MagalhãesInstituto de Medicina Integral Prof. Fernando Figueira - IMIP, Outpatient Dental Clinic, Recife, Pernambuco, Brazil. jackelineinacio1@live.com.
Fabiana Moura da Motta SilveiraInstituto de Medicina Integral Prof. Fernando Figueira - IMIP, Outpatient Dental Clinic, Recife, Pernambuco, Brazil.
Luciana Silva RegueiraInstituto de Medicina Integral Prof. Fernando Figueira - IMIP, Outpatient Dental Clinic, Recife, Pernambuco, Brazil.
Douglas Felipe de Lima E SilvaInstituto de Medicina Integral Prof. Fernando Figueira - IMIP, Outpatient Dental Clinic, Recife, Pernambuco, Brazil.
Samuel Rodrigo de Andrade VerasInstituto de Medicina Integral Prof. Fernando Figueira - IMIP, Outpatient Dental Clinic, Recife, Pernambuco, Brazil.
Maria Júlia Gonçalves de MelloInstituto de Medicina Integral Prof. Fernando Figueira - IMIP, Post-Graduation Program, Recife, Pernambuco, Brazil.
Instituto de Medicina Integral Professor Fernando Figueira · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the prophylaxis effect of pentoxifylline and tocopherol (PENTO) on the frequency and severity of medication-related osteonecrosis of the jaw (MRONJ) diagnosed at three months in patients with cancer submitted to tooth extractions during the treatment with bone-modifying agents.

methodsThis case series was conducted at the outpatient dental clinic of the Instituto de Medicina Integral Prof. Fernando Figueira (IMIP) between April 2021 and April 2022. Patients ≥ 18 years old were included; those with maxillary metastasis or who performed head or neck radiotherapy were excluded. The PENTO protocol was prescribed two weeks before and two weeks after the tooth extraction, and patients were reassessed one week, one month, and three months after the extraction. The main outcome was the development of MRONJ.

resultsOf the 114 screened patients, 17 were included; they were aged between 43 and 73 years and were mostly female (88.2%). Thirty-two tooth extractions were performed (22 in the maxilla and 10 in the mandible). Breast cancer was the most predominant neoplasm (70.6%), being metastatic in 35.3% of patients. Also, all patients used intravenous bisphosphonates. Stage 1 MRONJ was diagnosed in three patients (17.6%), representing three (9.4%) of all tooth extractions. The repair of MRONJ was achieved 30 days after the PENTO protocol.

conclusionThe prophylaxis use of PENTO reduced the severity of injuries, was well-tolerated, and showed patient compliance.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsBreast NeoplasmsPentoxifyllineAdolescentAdultAgedDiphosphonatesFemaleHumansMaleMiddle AgedTocopherolsTooth ExtractionBone Density Conservation AgentsDiphosphonatesPentoxifyllineTocopherolsOsteonecrosisPentoxifyllineTocopherolsTooth extraction

Identifiers

PMID37436539
OpenAlexW4383998972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.