Evidence map›Paper›PMID 37436461›Full record

Trial reportArchives of gynecology and obstetrics2024

The impact of early versus delayed cord clamping on hematological and cardiovascular changes in preterm newborns between 24 and 34 weeks' gestation: a randomized clinical trial.

Carolina García, María Teresa Prieto, Fuensanta Escudero, Vicente Bosh-Giménez, Lorenzo Quesada, Monika Lewanczyk, Miriam Pertegal, Juan Luis Delgado, Jose Eliseo Blanco-Carnero, Catalina De Paco Matallana

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07092319 (Impact of Delayed Cord Clamping and Minimally Invasive Surfactant Administration on Outcomes in Premature Infants With Neonatal Respiratory Distress Syndrome at Less Than 30 Weeks Gestation), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07092319 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Impact of Delayed Cord Clamping and Minimally Invasive Surfactant Administration on Outcomes in Premature Infants With Neonatal Respiratory Distress Syndrome at Less Than 30 Weeks Gestation: A NICU Quality Improvement Study

TypeobservationalSponsorPeking University Third HospitalRan2025 to 2027Enrolled518ConditionsNRDSArmsdeferred cord clamping
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Carolina GarcíaFetal Medicine Unit, Department of Obstetrics and Gynecology, Virgen de La Arrixaca University Hospital, 2nd Floor, Carretera Madrid-Cartagena S/N, El Palmar, 30120, Murcia, Spain.
María Teresa PrietoFetal Medicine Unit, Department of Obstetrics and Gynecology, Virgen de La Arrixaca University Hospital, 2nd Floor, Carretera Madrid-Cartagena S/N, El Palmar, 30120, Murcia, Spain.
Fuensanta EscuderoInstitute for Biomedical Research of Murcia, IMIB-Arrixaca, El Palmar, 30120, Murcia, Spain.
Vicente Bosh-GiménezDepartment of Surgery, Pediatrics, Obstetrics and Gynecology, University of Murcia, Murcia, Spain.
Lorenzo QuesadaIntensive Care Neonatal Unit, Department of Pediatrics, Virgen de La Arrixaca University Clinical Hospital, Murcia, Spain.
Monika LewanczykDepartment of Surgery, Pediatrics, Obstetrics and Gynecology, University of Murcia, Murcia, Spain.
Miriam PertegalFetal Medicine Unit, Department of Obstetrics and Gynecology, Virgen de La Arrixaca University Hospital, 2nd Floor, Carretera Madrid-Cartagena S/N, El Palmar, 30120, Murcia, Spain.
Juan Luis DelgadoFetal Medicine Unit, Department of Obstetrics and Gynecology, Virgen de La Arrixaca University Hospital, 2nd Floor, Carretera Madrid-Cartagena S/N, El Palmar, 30120, Murcia, Spain.
Jose Eliseo Blanco-CarneroFetal Medicine Unit, Department of Obstetrics and Gynecology, Virgen de La Arrixaca University Hospital, 2nd Floor, Carretera Madrid-Cartagena S/N, El Palmar, 30120, Murcia, Spain.
Catalina De Paco MatallanaFetal Medicine Unit, Department of Obstetrics and Gynecology, Virgen de La Arrixaca University Hospital, 2nd Floor, Carretera Madrid-Cartagena S/N, El Palmar, 30120, Murcia, Spain. Katy.depaco@gmail.com.
Hospital Universitario Virgen de la Arrixaca · ESInstituto Murciano de Investigación Biosanitaria · ESUniversidad de Murcia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to   investigate hematological and cardiac changes after early (ECC) versus delayed cord clamping (DCC) in preterm infants at 24-34 weeks of gestation.

methodsNinety-six healthy pregnant women were assigned randomly to the ECC (< 10 s postpartum, n = 49) or DCC (45-60 s postpartum, n = 47). Primary endpoint was evaluation of neonatal hemoglobin, hematocrit and bilirrubin levels within the first 7 days after birth. A postpartum blood test was performed in the mother and a neonatal echocardiography in the first week of life.

resultsWe found differences in hematological parameters during the first week of life. On admission, the DCC group had higher hemoglobin levels than the ECC group (18.7 ± 3.0 vs. 16.8 ± 2.4, p < 0.0014) and higher hematocrit values (53.9 ± 8.0 vs. 48.8 ± 6.4, p < 0.0011). Around day 7 of life, hemoglobin levels were also higher in the DCC group compared with the ECC group (16.4 ± 3.8 vs 13.9 ± 2.5, p < 0.005), as was the hematocrit (49.3 ± 12.7 vs 41.2 ± 8.4, p < 0.0087). The need of transfusion was lower in the DCC compared to the ECC (8.5% vs 24.5%; OR: 0.29, 95% CI: 0.09-0.97, p < 0.036). The need for phototherapy was also higher in the DCC (80.9% vs 63.3%; OR: 0.23, 95% CI: 0.06-0.84, p < 0.026). No differences in cardiac parameters or maternal blood tests.

conclusionDCC improved neonatal hematological parameters. No changes in cardiac function were found and maternal blood loss did not increase to require transfusion.

Indexed as

HemoglobinsInfant, PrematureUmbilical Cord ClampingAdultEchocardiographyFemaleGestational AgeHematocritHumansInfant, NewbornPregnancyTime FactorsHemoglobinsDelayed cord clampingEarly cord clampingNeonatalNeonatal outcomePretermSurfactantVentilation

Identifiers

PMID37436461
OpenAlexW4383998671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.