Evidence map›Paper›PMID 37436435›Full record

ArticleInternational urogynecology journal2023

Morphological changes in the anterior vaginal wall caused by aging: a scanning electron microscopy study.

Monique da Silva Dias Babinski, Lucas Alves Sarmento Pires, Evandro Mattos Lopes, Albino Fonseca, Jorge Henrique Martins Manaia, Marcio Antonio Babinski

Abstract read
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Article in International urogynecology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Monique da Silva Dias BabinskiExperimental Morphology Research Unit, Morphology Department, Fluminense Federal University, Av. Prof. Hernani Mello, 101 24.210-150, Niterói, Rio de Janeiro, Brazil.
Lucas Alves Sarmento PiresExperimental Morphology Research Unit, Morphology Department, Fluminense Federal University, Av. Prof. Hernani Mello, 101 24.210-150, Niterói, Rio de Janeiro, Brazil. lucaspires@id.uff.br.ORCID 0000-0002-2756-1794
Evandro Mattos LopesExperimental Morphology Research Unit, Morphology Department, Fluminense Federal University, Av. Prof. Hernani Mello, 101 24.210-150, Niterói, Rio de Janeiro, Brazil.
Albino FonsecaExperimental Morphology Research Unit, Morphology Department, Fluminense Federal University, Av. Prof. Hernani Mello, 101 24.210-150, Niterói, Rio de Janeiro, Brazil.
Jorge Henrique Martins ManaiaExperimental Morphology Research Unit, Morphology Department, Fluminense Federal University, Av. Prof. Hernani Mello, 101 24.210-150, Niterói, Rio de Janeiro, Brazil.
Marcio Antonio BabinskiExperimental Morphology Research Unit, Morphology Department, Fluminense Federal University, Av. Prof. Hernani Mello, 101 24.210-150, Niterói, Rio de Janeiro, Brazil.
Universidade Federal Fluminense · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001
6 · The paper itself

Abstract

introduction and hypothesisCollagen is a protein that confers robustness and resilience to several tissues. In the female reproductive system, collagen plays a critical role in maintaining the health and function of the vaginal walls. Aging leads to collagen reduction, which may cause vaginal dryness, irritation, and prolapse. We aim to analyze the structure and profile of collagen in the anterior vaginal wall of healthy pre-menopausal (pre-M) and post-menopausal (post-M) women under a scanning electron microscope (SEM).

methodsFragments of the anterior vaginal wall were collected and processed for light and scanning electron microscopy. Histological preparations were performed at first with Weigert's resorcin-fuchsin stain. Decellularized preparations were conducted, and the specimens were placed under an SEM to allow observation of the 3D organization of collagen.

resultsDecellularized preparations of the pre-M specimens showed a vaginal wall with an irregular subepithelial layer, organized with ECM projections. The subepithelium evidenced the network of collagen fibrils, which seemed to support the epithelium as a basal layer. In specimens of post-M, a fusion of a network of fibrils from different direction axes was evidenced, with plate formation observed in the subepithelial plane, disfiguring the structural organization of fibrils.

conclusionsOlder specimens showed a remodeling of collagen organization in comparison with younger samples of the anterior vaginal wall.

Indexed as

CollagenPelvic Organ ProlapseAgingExtracellular MatrixFemaleHumansMicroscopy, Electron, ScanningCollagenCollagenGynecologyHumanScanning electron microscopyVaginal wall

Identifiers

PMID37436435
OpenAlexW4383999170

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.