Trial reportEuropean journal of clinical pharmacology1986
Comparative efficacy of soluble aspirin and aspirin tablets in postoperative dental pain.
Trial report in European journal of clinical pharmacology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Single dose oral aspirin for acute postoperative pain in adults.The Cochrane database of systematic reviews · 2012Pooled it
- Prevention of postoperative swelling and pain by dexamethasone after operative removal of impacted third molar teeth.European journal of clinical pharmacology · 1993Trial
- An evaluation of buffered aspirin and aspirin tablets in postoperative pain after third molar surgery.British journal of clinical pharmacology · 1992Trial
- An evaluation of different doses of soluble aspirin and aspirin tablets in postoperative dental pain.British journal of clinical pharmacology · 1988Trial
- Comparative bioequivalence study of different brands of acetyl salicylic acid in human volunteers.European journal of drug metabolism and pharmacokineticsTrial
- Insoluble drug delivery strategies: review of recent advances and business prospects.Acta pharmaceutica Sinica. B · 2015Review
- Plasma esterase activity in patients with aspirin-sensitive asthma or urticaria.European journal of clinical pharmacology · 1987Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The efficacy of single doses (1.2 g) of soluble aspirin and aspirin tablets was determined in a randomised, placebo-controlled, double-blind, parallel study in 90 patients (45 females) with postoperative pain after removal of impacted lower third molars. Also investigated was the relationship between plasma aspirin esterase activity and overall pain scores after both aspirin preparations. Patients reported significantly less pain (p less than 0.001) after treatment with aspirin than after treatment with placebo. However, patients receiving soluble aspirin reported both an earlier onset and a longer duration of pain relief than those who received aspirin tablets. A significant correlation was observed between plasma aspirin esterase activity and overall pain scores after both soluble aspirin (r = 0.57, p less than 0.01) and aspirin tablets (r = 0.51, p less than 0.02). It is concluded that soluble aspirin is the preferred aspirin formulation for treating postoperative pain after third molar surgery and that plasma aspirin esterase activity is determinant of a patient's analgesic response to aspirin in postoperative dental pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.