Evidence map›Paper›PMID 37436268›Full record

ArticleEinstein (Sao Paulo, Brazil)2023

Amplifications of AURKA and AURKB in a Burkitt lymphoma immunodeficiency-associated type: a case report.

Fábio Morato de Oliveira, Vinícius Gonçalves de Souza, Aparecida de Lourdes Carvalho, Fermino Sanches Lizarte Neto, Carla Silva Siqueira Miranda

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Einstein (Sao Paulo, Brazil), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Fábio Morato de OliveiraUniversidade Federal de Jataí, Jataí, GO, Brazil.ORCID http://orcid.org/0000-0002-4821-445X
Vinícius Gonçalves de SouzaUniversidade Federal de Jataí, Jataí, GO, Brazil.ORCID http://orcid.org/0000-0002-1656-6928
Aparecida de Lourdes CarvalhoUniversidade Federal de Jataí, Jataí, GO, Brazil.ORCID http://orcid.org/0000-0001-8165-3633
Fermino Sanches Lizarte NetoFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.ORCID http://orcid.org/0000-0002-0046-7300
Carla Silva Siqueira MirandaUniversidade Federal de Jataí, Jataí, GO, Brazil.ORCID http://orcid.org/0000-0002-8749-2284
Universidade Federal de Jataí · BRUniversidade de Ribeirão Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In equatorial Brazil, the association of Burkitt lymphoma and Epstein-Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein-Barr virus, and /HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showed AURKA and AURKB amplification. The patient's condition worsened, progressing to death a month after the initial care. Changes in the MYCC and AURKA pathways are directly associated with genomic instability. Thus, MYCC rearrangements and higher expression of AURKA/B may be associated with therapy resistance, highlighting the importance of AURKA/B evaluation in Burkitt lymphoma.

Indexed as

Burkitt LymphomaEpstein-Barr Virus InfectionsImmunologic Deficiency SyndromesAdultAurora Kinase AAurora Kinase BHerpesvirus 4, HumanHumansMaleAURKA protein, humanAURKB protein, humanAurora Kinase AAurora Kinase B

Identifiers

PMID37436268
PMCPMC10317141
OpenAlexW4382023078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.