Evidence map›Paper›PMID 37436144›Full record

ArticleMicrobiology spectrum2023

Analysis of Bacterial Phosphorylcholine-Related Genes Reveals an Association between Type-Specific Biosynthesis Pathways and Biomolecules Targeted for Phosphorylcholine Modification.

Yuan Zhang, Freda E-C Jen, Jennifer L Edwards, Michael P Jennings

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yuan Zhang *Institute for Glycomics, Griffith University, Southport, Australia.
Freda E-C Jen *Institute for Glycomics, Griffith University, Southport, Australia.
Jennifer L EdwardsCenter for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0003-3568-0344
Michael P JenningsInstitute for Glycomics, Griffith University, Southport, Australia.ORCID 0000-0002-1027-4684
Griffith University · AUNationwide Children's Hospital · US

Funding

Novel carbohydrate binding functions of the CR3 I-domain modulate gonococcal-cervical cell interactionsR01AI134848 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI EDWARDS, JENNIFER L, JENNINGS, MICHAEL PAUL · 2018 to 2022
$2.2M
NIAID NIH HHS R01 AI134848
6 · The paper itself

Abstract

Many bacterial surface proteins and carbohydrates are modified with phosphorylcholine (ChoP), which contributes to host mimicry and can also promote colonization and survival in the host. However, the ChoP biosynthetic pathways that are used in bacterial species that express ChoP have not been systematically studied. For example, the well-studied Lic-1 pathway is absent in some ChoP-expressing bacteria, such as Neisseria meningitidis and Neisseria gonorrhoeae. This raises a question as to the origin of the ChoP used for macromolecule biosynthesis in these species. In the current study, we used

Indexed as

Biosynthetic PathwaysPhosphorylcholineBacterial ProteinsFimbriae ProteinsTransferasesBacterial ProteinsFimbriae ProteinsPhosphorylcholineTransferasesbacterial virulenceChoPphosphatidylcholinephosphoethanolaminephosphorylcholine

Identifiers

PMID37436144
PMCPMC10434233
OpenAlexW4383998047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.