Evidence map›Paper›PMID 37435740›Full record

ArticleCNS oncology2023

Long-term survival after salvage pemetrexed for refractory primary T-cell lymphoma of the CNS.

Andy Liu, Huda Alalami, Xuemo Fan, Chirag Patil, Jaya M Gill, Santosh Kesari, Jethro Hu

Open access · goldAbstract readCase Reports
In one paragraph

Article in CNS oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andy LiuPacific Neuroscience Institute & Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA 90404, USA.ORCID 0000-0002-8312-6906
Huda AlalamiCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0003-3434-9043
Xuemo FanCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Chirag PatilCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Jaya M GillPacific Neuroscience Institute & Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA 90404, USA.ORCID 0000-0003-3608-4392
Santosh KesariPacific Neuroscience Institute & Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA 90404, USA.
Jethro HuCedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0002-5450-7988
Cedars-Sinai Medical Center · USSaint John's Health Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary T-cell CNS lymphoma is a rare and aggressive malignancy. High-dose methotrexate (MTX) based chemotherapy regimens are used as standard first-line treatment, followed by consolidative strategies to improve the duration of response. Although MTX-based therapy has been shown to be efficacious, treatment options for MTX-refractory disease are not well-defined. Here, we report a case of a 38-year-old man with refractory primary T-cell CNS lymphoma who demonstrated a complete response to pemetrexed treatment. He subsequently received conditioning chemotherapy consisting of thiotepa, busulfan and cyclophosphamide followed by autologous stem cell transplantation. The patient continues to remain recurrence-free to date at 9 years post-treatment.

Indexed as

Central Nervous System NeoplasmsHematopoietic Stem Cell TransplantationLymphoma, T-CellAdultAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyHumansMalePemetrexedTransplantation, AutologousPemetrexedcase reportPCNSLpemetrexedT cellT-cell lymphoma

Identifiers

PMID37435740
PMCPMC10410685
OpenAlexW4383999320

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.