Evidence map›Paper›PMID 37435562›Full record

ReviewTherapeutic advances in medical oncology2023

Radiation and immune checkpoint inhibitors in the treatment of oligometastatic non-small-cell lung cancer: a practical review of rationale, recent data, and research questions.

Sondos Zayed, Alexander V Louie, Daniel A Breadner, David A Palma, Rohann J M Correa

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in medical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06207292 (STereotactic Ablative RadioTherapy in NEWly Synchronous and mEtachRonous), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06207292 naunknown statusnot on this map

STereotactic Ablative RadioTherapy in NEWly Synchronous and mEtachRonous (Oligo-persistence, Oligo-induced, Oligo-progression) Oncogene and Non Oncogene Addicted OLIGO-metastatic Non-small Cell Lung Cancer Patients

TypeinterventionalSponsorRadiotherapy Oncology Centre "Santa Maria" HospitalRan2016 to 2024Enrolled100ConditionsNSCLC, NSCLC Stage IV, Oligometastatic Disease, Non Small Cell Lung CancerArmsStereotactic Ablative Radiotherapy
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Mathematical Modeling Support for Lung Cancer Therapy-A Short Review.International journal of molecular sciences · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sondos ZayedDepartment of Radiation Oncology, London Health Sciences Centre, London, ON, Canada.
Alexander V LouieDepartment of Radiation Oncology, Sunnybrook Hospital Odette Cancer Centre, Toronto, ON, Canada.
Daniel A BreadnerDepartment of Medical Oncology, London Health Sciences Centre, London, ON, Canada.ORCID https://orcid.org/0000-0001-5379-7621
David A PalmaDepartment of Radiation Oncology, London Health Sciences Centre, London, ON, Canada.
Rohann J M CorreaDepartment of Radiation Oncology, London Health Sciences Centre, 800 Commissioners Rd East, London, ON N6A 5W9, Canada.
London Health Sciences Centre · CASunnybrook Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The combined use of stereotactic ablative radiotherapy (SABR) and immune checkpoint inhibitors (ICIs) is an emerging treatment paradigm for oligometastatic non-small-cell lung cancer (NSCLC). Recent phase I and II trial data suggest that SABR to multiple metastases in addition to ICI use is safe and effective with promising progression-free survival and overall survival signals. There is great interest in capitalizing on combined immunomodulation from these two modalities for the treatment of oligometastatic NSCLC. Ongoing trials seek to validate the safety, efficacy, and preferred sequencing of SABR and ICI. This narrative review of the role of SABR when combined with ICI in oligometastatic NSCLC discusses the rationale for this bimodality treatment, summarizes recent clinical trial evidence, and proposes key principles of management based on the available evidence.

Indexed as

immune checkpoint inhibitorsimmunotherapynon-small-cell lung canceroligometastasisstereotactic ablative radiotherapy

Identifiers

PMID37435562
PMCPMC10331344
OpenAlexW4383647203

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.