Evidence map›Paper›PMID 37435412›Full record

ArticleJournal of hematology2023

Donor Cell Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation.

Ahmed Khattab, Sunita Patruni, Gina Patrus, Yazan Samhouri, Salman Fazal, John Lister

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Journal of hematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ahmed KhattabDepartment of Medical Oncology and Hematology, Allegheny Health Network, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-9845-3427
Sunita PatruniDepartment of Medical Oncology and Hematology, Northwell Health, Lake Success, NY, USA.
Gina PatrusDivision of Hematology and Cellular Therapy, Allegheny Health Network, Pittsburgh, PA, USA.
Yazan SamhouriDivision of Hematology and Cellular Therapy, Allegheny Health Network, Pittsburgh, PA, USA.
Salman FazalDivision of Hematology and Cellular Therapy, Allegheny Health Network, Pittsburgh, PA, USA.
John ListerDivision of Hematology and Cellular Therapy, Allegheny Health Network, Pittsburgh, PA, USA.
Allegheny Health Network · USNorthwell Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 25,000 allogeneic transplants are performed annually worldwide; a figure that has steadily increased over the past three decades. The study of transplant recipient survivorship has become a cogent topic and post-transplant donor cell pathology warrants further study. Donor cell leukemia (DCL) is a rare but serious complication of allogeneic stem cell transplantation (SCT) where the recipient develops a form leukemia originating from the donor cells used for transplantation. Detection of abnormalities predicting donor cell pathology might inform donor selection, and the design of survivorship programs for early detection of these abnormalities might allow therapeutic intervention earlier in the disease course. We present four recipients of allogeneic hematopoietic stem cell transplant (HSCT) from our institution who developed donor cell abnormalities allogeneic SCT, highlighting their clinical characteristics and challenges.

Indexed as

Age-related clonal hematopoiesisAllogeneicClonal hematopoiesis of indeterminant potentialHematopoietic stem cell transplantationStem cell transplant

Identifiers

PMID37435412
PMCPMC10332864
OpenAlexW4383561141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.