Evidence map›Paper›PMID 37435226›Full record

ArticleJournal of gastrointestinal oncology2023

Pre-operative chemoradiotherapy with or without induction chemotherapy for operable locally-advanced esophageal cancer.

Gabrielle W Peters, Wesley Talcott, Nicholas V Peters, Andrew Dhanasopan, Jill Lacy, Michael Cecchini, Jeremy Kortmansky, Stacey Stein, Stephen Lattanzi, Henry S Park and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of gastrointestinal oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Gabrielle W PetersDepartment of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.
Wesley TalcottDepartment of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.
Nicholas V PetersDepartment of General Surgery, Yale University School of Medicine, New Haven, CT, USA.
Andrew DhanasopanDepartment of Thoracic Surgery, Yale University School of Medicine, New Haven, CT, USA.
Jill LacyDepartment of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA.
Michael CecchiniDepartment of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA.
Jeremy KortmanskyDepartment of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA.
Stacey SteinDepartment of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA.
Stephen LattanziDepartment of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA.
Henry S ParkDepartment of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.
Daniel BoffaDepartment of Thoracic Surgery, Yale University School of Medicine, New Haven, CT, USA.
Kimberly L JohungDepartment of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.
Krishan R JethwaRadiation Oncology, Mayo Clinic, Rochester, MN, USA.
Yale University · USMayo Clinic in Arizona · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Background: For patients with operable locally advanced esophageal carcinoma (LA-EC), we hypothesized that pre-operative induction chemotherapy followed by chemoradiotherapy (IC-CRT) would improve progression-free survival (PFS) and overall survival (OS) when compared to chemoradiotherapy (CRT). Methods: This was a single institution retrospective cohort study including patients with LA-EC who received preoperative-intent IC-CRT Results: Ninty-five patients were included for analysis (IC-CRT n=59; CRT n=36) and the median follow-up was 37.7 months (IQR: 16.8-56.1). There was no difference in median PFS or OS for IC-CRT or CRT, 22 months (95% CI: 12-59) Conclusions: For patients with LA-EC, preoperative-intent IC-CRT was not associated with improved PFS or OS when compared with CRT.

Indexed as

esophageal cancergastroesophageal cancerInduction chemotherapy

Identifiers

PMID37435226
PMCPMC10331751
OpenAlexW4382600488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.