ArticleInnovation in aging2023
Multimorbidity and Quality of Life: The Mediating Role of ADL, IADL, Loneliness, and Depressive Symptoms.
Article in Innovation in aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of quality of life (QoL) studies using the CASP scale in older adults.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Patterns of Vulnerability: Frailty, Multimorbidity, and Physical Health-Related Quality of Life in Institutionalised Older Adults.Healthcare (Basel, Switzerland) · 2026Article
- The mediating role of activities of daily living in the association between intrinsic capacity and health-related quality of life: evidence from the WHO ICOPE pilot in China.Aging clinical and experimental research · 2026Article
- Lifestyle and psychosocial determinants of quality of life in Turkish community-dwelling older adults: a multivariate and hierarchical regression approach.BMC geriatrics · 2026Article
- Linkages between functional independence, depressive symptoms, and social networks in aging populations: a systematic review.Journal of exercise rehabilitation · 2026Review
- Loneliness among older adults with multiple chronic conditions: Exploring disparities for Hispanic adults in the 2023 Behavioral Risk Factor Surveillance System.Public health · 2026Observational
- Development of a Quality Assessment Index System for Palliative Care Services in Chinese Nursing Homes: A Modified Delphi and Analytic Hierarchy Process Study.Journal of nursing management · 2026Article
- Impact of multimorbidity on health-related quality of life: the mediation role of intrinsic capacity - evidence from the WHO ICOPE pilot program in Lianyungang of China (2024).Archives of public health = Archives belges de sante publique · 2025Article
- Depressive Symptoms and Physical Activity Mediate the Adverse Effect of Pain on Functional Dependence in Patients With Arthritis: Evidence From the Canadian Longitudinal Study on Aging.Physical therapy · 2025Article
- Frailty, multimorbidity and quality of life in an ageing population in Africa: a cross-sectional, population-based study in rural and urban Rwanda.Family medicine and community health · 2025Article
- Exploring Risk Factors Related to Low Calf Circumference in Older Adults With Multimorbidity: Cross-Sectional Latent Class Analysis.JMIR aging · 2025Article
- Experiences of Social Relationships for Adults Living With Multiple Long-Term Conditions: A Qualitative Interview Study.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- Associations of Objective and Subjective Physical Function With Quality of Life and Well-Being: A Cross-Sectional Study From Ardakan Cohort Study on Aging (ACSA).Health science reports · 2025Article
- Neonatal multimorbidity and the phenotype of premature aging in preterm infants.Pediatric research · 2025Review
- The impact of active social media use on the mental health of older adults.BMC psychology · 2025Article
- Article
- Moderating effect of instrumental activities of daily living on the relationship between loneliness and depression in people with cognitive frailty.BMC geriatrics · 2025Article
- Relation of Social Participation Restrictions with Worsening Quality of Life in Japanese Patients with Behçet's Disease: The 36-item Short Form Survey.JMA journal · 2025Article
- Longitudinal study on health-related quality of life and multimorbidity: from trajectories to outcomes in China.Frontiers in public health · 2025Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: The ubiquity of multimorbidity makes it crucial to examine the intermediary factors linking it with quality of life (QoL). The objective was to examine to what extent the association between multimorbidity and QoL was mediated by functional and emotional/mental health and how these mediation pathways differed by sociodemographic factors (age, gender, education, and financial strain). Research Design and Methods: Data from Waves 4 to 8 of 36,908 individuals from the Survey of Health, Aging, and Retirement in Europe (SHARE) were included. Multimorbidity (exposure) was defined as having 2 or more chronic conditions. Mediators included limitations with (instrumental) activities of daily living (ADL and IADL), loneliness, and depressive symptoms. QoL (outcome) was assessed with the CASP-12 scale. Longitudinal model-based causal mediation analyses were performed to decompose the total association between multimorbidity and QoL into direct and indirect effects. Moderated mediation analyses tested for differences in mediation pathways by sociodemographic factors. Results: Multimorbidity was significantly associated with lower QoL (direct effect: Discussion and Implications: ADL, IADL, and depressive symptoms are crucial intermediary factors between multimorbidity and QoL in older European adults, with changing importance according to age, education, financial strain, and gender. The findings may help to increase the QoL of individuals with multimorbidity and redirect care efforts to these factors.
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