Evidence map›Paper›PMID 37435079›Full record

ReviewFrontiers in immunology2023

Complex interactions of cellular players in chronic Graft-versus-Host Disease.

Laura Marie Gail, Kimberly Julia Schell, Piotr Łacina, Johanna Strobl, Steven J Bolton, Emilie Steinbakk Ulriksen, Katarzyna Bogunia-Kubik, Hildegard Greinix, Rachel Emily Crossland, Marit Inngjerdingen and 1 more

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura Marie GailDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Kimberly Julia SchellTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Piotr ŁacinaLaboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Johanna StroblDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Steven J BoltonTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Emilie Steinbakk UlriksenDepartment of Pharmacology, Oslo University Hospital, Oslo, Norway.
Katarzyna Bogunia-KubikLaboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Hildegard GreinixDepartment of Internal Medicine, Division of Hematology, Medical University of Graz, Graz, Austria.
Rachel Emily CrosslandTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Marit InngjerdingenDepartment of Pharmacology, Oslo University Hospital, Oslo, Norway.
Georg StaryDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects many patients after allogeneic hematopoietic stem cell transplantation. Although we have made substantial progress in understanding disease pathogenesis and the role of specific immune cell subsets, treatment options are still limited. To date, we lack a global understanding of the interplay between the different cellular players involved, in the affected tissues and at different stages of disease development and progression. In this review we summarize our current knowledge on pathogenic and protective mechanisms elicited by the major involved immune subsets, being T cells, B cells, NK cells and antigen presenting cells, as well as the microbiome, with a special focus on intercellular communication of these cell types

Indexed as

Bronchiolitis Obliterans SyndromeExtracellular VesiclesAntigen-Presenting CellsB-LymphocytesCell CommunicationHumanscell-cell communicationchronic graft-versus-host diseaseGvHD pathogenesishematopoietic stem cell transplantationimmune cell networks

Identifiers

PMID37435079
PMCPMC10332803

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.