Evidence map›Paper›PMID 37435068›Full record

ArticleFrontiers in immunology2023

Loss of the mammalian G-protein coupled receptor, G2A, modulates severity of invasive pulmonary aspergillosis.

Breanne N Steffan, Dante Calise, Sung Chul Park, Mengyao Niu, Jun Yang, Bruce D Hammock, MaryJane Jones, Chad Steele, Nancy P Keller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. ZfpA-regulated chitin synthesis inAntimicrobial agents and chemotherapy · 2026
    Article
  2. Article
  3. Review
  4. Murine Alox8 versus the human ALOX15B ortholog: differences and similarities.Pflugers Archiv : European journal of physiology · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Breanne N SteffanDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, United States.
Dante CaliseDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, United States.
Sung Chul ParkDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, United States.
Mengyao NiuDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, United States.
Jun YangDepartment of Entomology, University of California-Davis, Davis, CA, United States.
Bruce D HammockDepartment of Entomology, University of California-Davis, Davis, CA, United States.
MaryJane JonesDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA, United States.
Chad SteeleDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA, United States.
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, United States.
University of Wisconsin–Madison · USTulane University · USUniversity of California, Davis · US

Funding

Molecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
Immunopathogenesis in fungal asthmaR01HL122426 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Chad Steele · 2015 to 2026
$5.1M
Biology of innate IL-22 during lung fungal infectionR01HL136211 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEELE, CHAD · 2017 to 2024
$3.0M
Bidirectional paracrine signaling in the establishment of invasive aspergillosisR01AI150669 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KELLER, NANCY P · 2021 to 2025
$2.4M
NHLBI NIH HHS R01 HL122426NHLBI NIH HHS R01 HL136211NIAID NIH HHS R01 AI150669NIEHS NIH HHS R35 ES030443NIEHS NIH HHS T32 ES007015
6 · The paper itself

Abstract

Background: Materials and methods: Oxylipins were extracted from infected lung tissue to assess fungal oxylipin production and the Pathhunter β-arrestin assay was used to assess agonist and antagonist activity by fungal oxylipins on G2A. An immunocompetent model of Results: Here we report that Conclusions: We conclude that G2A suppresses host inflammatory responses to

Indexed as

Invasive Pulmonary AspergillosisReceptors, G-Protein-CoupledAnimalsAspergillus fumigatusCell Cycle ProteinsMiceOxylipinsCell Cycle ProteinsG2A receptorOxylipinsReceptors, G-Protein-CoupledaspergillosisAspergillus fumigatusG2AGPR132hydroxyoctadecadienoic acidlungneutrophiloxylipin

Identifiers

PMID37435068
PMCPMC10331294
OpenAlexW4382136377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.