ArticleAmerican journal of translational research2023
Prognostic value of coagulation and fibrinolysis function indexes and NETs for sepsis patients.
Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Neutrophil Extracellular Traps in the Prognosis of Sepsis: A Current Update.Medicina (Kaunas, Lithuania) · 2025Review
- [GSK484, a PAD4 inhibitor, improves endothelial dysfunction in mice with sepsis-induced lung injury by inhibiting H3Cit expression].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo clarify the role of coagulation and fibrinolysis as well as the level of neutrophil extracellular traps (NETs) in patients with sepsis, and to explore their clinical significance in identifying the disease and predicting the prognosis.
methodsIn this retrospective study, the clinical data from 120 patients with sepsis admitted to People's Hospital of Changshou from January 2019 to December 2021 were analyzed. The patients were divided into a survival group and a death group according to the survival of patients within 28 days of admission. Another 120 patients with common bacterial infection were selected as the bacterial group and 120 healthy subjects who underwent physical examination in our hospital during the same period were selected as the healthy group. NETs, coagulation and fibrinolysis indexes, prothrombin time (PT), fibrinogen (FIB), D-dimer level, International Normalized Ratio (INR), Acute Physiology and Chronic Health Evaluation (APACHE) II score, and sequential organ failure assessment (SOFA) score of the patients with sepsis were compared with those of bacterial group and healthy group. Correlations between these measures were analyzed, and the predictive value of NETs for survival in patients with sepsis was assessed.
resultsCompared with bacterial group and healthy group, the levels of serum NETs, PT, FIB, D-dimer, and INR value in sepsis patients were significantly increased. The level of NETs was positively associated with APACHE II score, SOFA score, PT, FIB, D-dimer, and INR. INR showed good performance in predicting death within 28 days after admission in sepsis patients.
conclusionThe NETs and coagulation indexes have high predictive value for the prognosis of patients with sepsis.
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37434850PMC10331652W4383999296What OpenQuestion holds
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