ArticleAmerican journal of translational research2023
Correlation of serum Orexin-A level with cognitive function and serum inflammatory cytokines in epileptic patients.
Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 3 citations in OpenAlex.
- Temporal profile of serum orexin-A in neonatal hypoxic-ischemic encephalopathy: a prospective longitudinal study.BMC pediatrics · 2026Observational
- The orexin system as a pharmacological target in inflammation: peripheral mechanisms and safety implications.Frontiers in pharmacology · 2026Review
- Orexin-A Mitigates Traumatic Brain Injury by Inhibiting Neuronal Ferroptosis Through Orexin Receptor 1/Nuclear Factor Erythroid 2-Related Factor 2 Signaling Pathway.Molecular neurobiology · 2025Article
- Targeting the Orexin System in the Pharmacological Management of Insomnia and Other Diseases: Suvorexant, Lemborexant, Daridorexant, and Novel Experimental Agents.International journal of molecular sciences · 2025Review
- Analysis of influencing factors for cognitive impairment in children with self-limited epilepsy with centrotemporal spikes.Frontiers in neurologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was designed to analyze the associations of serum Orexin-A level with cognitive function and serum inflammatory cytokines in epileptic patients.
methodsTotally 77 epileptic patients treated in Suqian First Hospital between January 2019 and January 2022 were retrospectively analyzed as the observation group, and 65 healthy individuals who had a physical examination in Suqian First Hospital during the same period were enrolled as the control group. The Mini-Mental State Examination (MMSE) was conducted in participants in the two groups, and the enzyme-linked immunosorbent assay (ELISA) was conducted for quantifying serum Orexin-A, interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Additionally, the Pearson correlation test was used for analyzing the associations of Orexin-A with MMSE, IL-1β, IL-6, and TNF-α in the patients, and receiver operating characteristic (ROC) curves were drawn for determining the diagnostic value of Orexin-A in epilepsy and cognitive dysfunction in epileptic patients. The independent risk factors for cognitive impairment in epileptic patients were analyzed by multivariate logistic regression analysis.
resultsEpileptic patients showed a significantly lower serum Orexin-A level than the control group (P < 0.05), and the area under the curve (AUC) of Orexin-A in epilepsy diagnosis was 0.879. Additionally, epileptic patients had notably lower MMSE scores than the control group (P < 0.05). The Pearson correlation test revealed a positive association of Orexin-A with MMSE score and negative correlations of Orexin-A with IL-1β, IL-6, and TNF-α levels (P < 0.05). The AUC of Orexin-A in diagnosing cognitive dysfunction in epileptic patients was 0.908. According to multivariate analysis, lower education level, more severe EEG abnormalities and a lower Orexin-A level were independent risk factors for cognitive impairment in epileptic patients.
conclusionOrexin-A can act as a diagnostic marker for epileptic patients, and its level is positively related with cognitive function of patients, but negatively related to the degree of inflammation. It is promising to be an early warning index for epilepsy and cognitive dysfunction in patients.
Indexed as
Identifiers
37434836PMC10331673W4383998158What OpenQuestion holds
Registered trials
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