ArticleAmerican journal of translational research2023
A ferroptosis-related ceRNA network in hepatocellular carcinoma for potential clinical applications.
Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Article
- Curculigoside alleviates ferroptosis in renal interstitial fibrosis by regulating the Nrf2/HO-1 signaling pathway.American journal of translational research · 2025Article
- The role of competing endogenous RNA network in the development of hepatocellular carcinoma: potential therapeutic targets.Frontiers in cell and developmental biology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the competing endogenous RNA (ceRNA) network related to ferroptosis in hepatocellular carcinoma (HCC) and its promise for clinical application.
methodsWe obtained RNA sequencing data for HCC and relevant clinical information from The Cancer Genome Atlas (TCGA) database. To assess the involvement of the autophagy, pyroptosis, and ferroptosis pathways in HCC, we used single-sample Gene Set Enrichment Analysis (ssGSEA) to compute scores for each sample based on pre-defined gene sets. We conducted Weighted Gene Co-Expression Network Analysis (WGCNA) to effectively modularize lncRNA, miRNA, and mRNA. Through extensive correlation analyses, we pinpointed the most crucial ferroptosis-associated modules. Moreover, we utilized online prediction tools to construct a corresponding ceRNA network. To establish the reliability of our results, we randomly chose a ceRNA axis consisting of DNAJC27-AS1/miR-23b-3p/PPIF for experimental validation. We performed luciferase reporter assays to validate the binding sites of DNAJC27-AS1, miR-23b-3p, and PPIF.
resultsWe found a significant correlation between the level of ferroptosis and the overall survival of patients with HCC. Thus, we constructed a comprehensive ferroptosis-related ceRNA network. Our experimental findings revealed that DNAJC27-AS1 and PPIF act as direct sponges of miR-23b-3p, and thus are capable of downregulating ferroptosis in HCC cells.
conclusionThe ferroptosis-associated ceRNA network presented in this study represents a valuable resource for advancing our understanding of the role of ferroptosis in HCC.
Indexed as
Identifiers
37434825PMC10331659W4383998100What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.