Evidence map›Paper›PMID 37434808›Full record

ArticleAmerican journal of translational research2023

Public acceptability of lumbar puncture in the diagnosis of Alzheimer's disease: a questionnaire-based single center study in China.

Xiaojuan Guo, Ling Gao, Jie Liu, Wenhui Lu, Jin Wang, Qiumin Qu

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Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Nuclear medicine and molecular imaging · 2025
    Article
  2. Article
  3. Article
  4. Incremental value of amyloid PET in a tertiary memory clinic setting in China.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  5. Article
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xiaojuan GuoDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China.
Ling GaoDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China.
Jie LiuDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China.
Wenhui LuDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China.
Jin WangDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China.
Qiumin QuDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate public acceptability of lumbar puncture in the diagnosis of Alzheimer's disease and to find out the factors influencing patient decision.

methodsWe administered a questionnaire to participants who were native to Xi'an using the "Sojump" application. Participants were required to answer the questionnaire on their cell phones following the instructions. The questions of the questionnaire were divided into four categories, including demographic data, awareness of lumbar puncture, attitudes toward lumbar puncture for the diagnosis of Alzheimer's disease, and reasons for negative attitude. Logistic regression was used to analyze the factors influencing the attitude toward lumbar puncture testing.

resultsA total of 1050 valid questionnaires were collected, including 403 (38.4%) from non-medical personnel and 647 (61.6%) from medical personnel. Among them, 35.7% of the participants knew about lumbar puncture examinations. Regarding the attitude, 862 participants (82.1%) had a positive attitude toward lumbar puncture in the diagnosis of Alzheimer's disease, and 508 (58.9%) of them considered lumbar puncture to be helpful in confirming the diagnosis. Multivariate analysis revealed that factors associated with a positive attitude in the non-medical group included age (OR=0.963, P=0.003, 95% CI: 0.939-0.987), education level (OR=2.073, P=0.037, 95% CI: 1.044-4.114), monthly income (OR=1.340, P=0.031, 95% CI: 1.028-1.748), and type of occupation (OR=1.569, P=0.038, 95% CI: 1.026-2.400). Factors associated with a positive attitude in the medical group included place of residence (OR=9.182, P=0.036, 95% CI: 1.151-73.238), monthly income (OR=4.008, P=0.002, 95% CI: 1.689-9.511), and hospital level (OR=38.311, P < 0.001, 95% CI: 14.323-102.478).

conclusionsMore than 80% of the public has a positive attitude towards lumbar puncture in the diagnosis of Alzheimer's disease, suggesting high acceptability. However, the attitude toward lumbar puncture is depend on age, education level, economic status, and type of occupation.

Indexed as

Alzheimer’s diseasebiomarkersdiagnosislumbar puncturequestionnaires

Identifiers

PMID37434808
PMCPMC10331662

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.