Evidence map›Paper›PMID 37434761›Full record

ArticleFrontiers in neuroscience2023

Redistribution of the astrocyte phenotypes in the medial vestibular nuclei after unilateral labyrinthectomy.

Jie Li, Pengjun Wang, Lu-Yang Wang, Yaqin Wu, Jiping Wang, Dongzhen Yu, Zhengnong Chen, Haibo Shi, Shankai Yin

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Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jie LiDepartment of Otorhinolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Pengjun WangDepartment of Otorhinolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Lu-Yang WangPrograms in Neurosciences & Mental Health, SickKids Research Institute and Department of Physiology, University of Toronto, Toronto, ON, Canada.
Yaqin WuDepartment of Otorhinolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Jiping WangDepartment of Otorhinolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Dongzhen YuDepartment of Otorhinolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhengnong ChenDepartment of Otorhinolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Haibo ShiDepartment of Otorhinolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shankai YinDepartment of Otorhinolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrocytes are highly heterogeneous and involved in different aspects of fundamental functions in the central nervous system (CNS). However, whether and how this heterogeneous population of cells reacts to the pathophysiological challenge is not well understood. To investigate the response status of astrocytes in the medial vestibular nucleus (MVN) after vestibular loss, we examined the subtypes of astrocytes in MVN using single-cell sequencing technology in a unilateral labyrinthectomy mouse model. We discovered four subtypes of astrocytes in the MVN with each displaying unique gene expression profiles. After unilateral labyrinthectomy, the proportion of the astrocytic subtypes and their transcriptional features on the ipsilateral side of the MVN differ significantly from those on the contralateral side. With new markers to detect and classify the subtypes of astrocytes in the MVN, our findings implicate potential roles of the adaptive changes of astrocyte subtypes in the early vestibular compensation following peripheral vestibular damage to reverse behavioral deficits.

Indexed as

astrocytelabyrinthectomyplasticitysingle-cell RNA seqvestibular compensation

Identifiers

PMID37434761
PMCPMC10330711

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.