ArticleJournal of the Royal Society, Interface2023
Cooperative melting in double-stranded peptide chains through local mechanical interactions.
Article in Journal of the Royal Society, Interface, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Effects of Temperature and Random Forces in Phase Transformation of Multi-Stable Systems.Entropy (Basel, Switzerland) · 2024Article
- Cooperative melting in double-stranded peptide chains through local mechanical interactions.Journal of the Royal Society, Interface · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The separation of double-stranded peptide chains can occur in two ways: cooperatively or non-cooperatively. These two regimes can be driven either by chemical or thermal effects, or through non-local mechanical interactions. Here, we show explicitly that local mechanical interactions in biological systems may regulate the stability, the reversibility, and the cooperative/non-cooperative character of the debonding transition. We show that this transition is characterized by a single parameter depending on an internal length scale. Our theory describes a wide range of melting transitions found in biological systems such as protein secondary structures, microtubules and tau proteins, and DNA molecules. In these cases, the theory gives the critical force as a function of the chain length and its elastic properties. Our theoretical results provide quantitative predictions for known experimental effects that appear in different biological and biomedical fields.
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