SynthesisCritical care (London, England)2023
Early hyperbaric oxygen therapy is associated with favorable outcome in patients with iatrogenic cerebral arterial gas embolism: systematic review and individual patient data meta-analysis of observational studies.
Synthesis in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 25 citations in OpenAlex.
- Resolution of Pneumomediastinum, Cervicofacial Emphysema, and Internal Ophthalmoplegia with Hyperbaric Oxygen Therapy After Hip Arthroscopy: A Case Report.Journal of clinical medicine · 2026Article
- Medical care in submarine accidents.Critical care (London, England) · 2026Review
- Technical feasibility of hyperbaric oxygen therapy for gas embolism with ECMO support: a brief report.Critical care (London, England) · 2026Article
- From shadows to light: navigating the rare complication of cerebral air embolism from a case report.Frontiers in medicine · 2026Article
- Hyperbaric Oxygen Therapy for Cognitive Impairment Resulting from Neurological Disorders: Mechanisms of Action and Application Advances.International journal of medical sciences · 2026Review
- Functional outcome and quality of life after iatrogenic cerebral air embolism treated with hyperbaric oxygen: a prospective cohort study.Diving and hyperbaric medicine · 2025Observational
- Impact of hyperbaric oxygenation therapy (HBOT) on renal function in human.Scientific reports · 2025Article
- Cerebral gas embolism in a patient without right-to-left shunt after robotic partial nephrectomy.JA clinical reports · 2025Article
- Cerebral air embolism after accidental air injection into a radial artery sheath.Cardiovascular intervention and therapeutics · 2025Article
- Cerebral air embolism in pediatric patients undergoing cardiac surgery.Journal of cardiothoracic surgery · 2024Article
- Lateral ST-elevation myocardial infarction from systemic air embolism after CT guided lung biopsy.Diving and hyperbaric medicine · 2024Article
- Secondary deterioration in a patient with cerebral and coronary arterial gas embolism after brief symptom resolution: a case report.Diving and hyperbaric medicine · 2024Article
- Decompression illness: a comprehensive overview.Diving and hyperbaric medicine · 2024Article
- Effect of a helium and oxygen mixture on physiological parameters of rats with cerebral arterial air embolism.Frontiers in physiology · 2024Article
- Cerebral air embolism following a hemodialysis session successfully treated with hyperbaric oxygen: a case report.Therapeutic advances in neurological disorders · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIatrogenic cerebral arterial gas embolism (CAGE) caused by invasive medical procedures may be treated with hyperbaric oxygen therapy (HBOT). Previous studies suggested that initiation of HBOT within 6-8 h is associated with higher probability of favorable outcome, when compared to time-to-HBOT beyond 8 h. We performed a group level and individual patient level meta-analysis of observational studies, to evaluate the relationship between time-to-HBOT and outcome after iatrogenic CAGE.
methodsWe systematically searched for studies reporting on time-to-HBOT and outcome in patients with iatrogenic CAGE. On group level, we meta-analyzed the differences between median time-to-HBOT in patients with favorable versus unfavorable outcome. On individual patient level, we analyzed the relationship between time-to-HBOT and probability of favorable outcome in a generalized linear mixed effects model.
resultsGroup level meta-analysis (ten studies, 263 patients) shows that patients with favorable outcome were treated with HBOT 2.4 h (95% CI 0.6-9.7) earlier than patients with unfavorable outcome. The generalized linear mixed effects model (eight studies, 126 patients) shows a significant relationship between time-to-HBOT and probability of favorable outcome (p = 0.013) that remains significant after correcting for severity of manifestations (p = 0.041). Probability of favorable outcome decreases from approximately 65% when HBOT is started immediately, to 30% when HBOT is delayed for 15 h.
conclusionsIncreased time-to-HBOT is associated with decreased probability of favorable outcome in iatrogenic CAGE. This suggests that early initiation of HBOT in iatrogenic CAGE is of vital importance.
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